Stockholm University
The Wenner-Gren Institute
Immunology
Svante Arrheniusväg 22, room F562
106 91 Stockholm
Sweden

Email: eva.sverremark@imun.su.se
Phone: 00 46 8 16 41 78
Fax: 00 46 8 612 95 42

Immune maturation and allergy development during childhood in relation to early-life microbial exposures

Babies are born with an immature immune system, which gradually matures during their first year(s) of life. This maturation is dependent on environmental exposures such as the establishment of a gut flora and exposure to various infections, but also on exposure to microbial compounds.
 

Johansson MA, Sjögren YM, Persson JO, Nilsson C, Sverremark-Ekström E.
Early colonization with a group of Lactobacilli decreases the risk for allergy at five years of age despite allergic heredity.
PLoS One. 2011;6(8):e23031. Epub 2011 Aug 1.
PMID:21829685

Sohlberg E, Saghafian-Hedengren S, Bremme K, Sverremark-Ekström E.
Cord blood monocyte subsets are similar to adult and show potent peptidoglycan-stimulated cytokine responses.
Immunology. 2011 May;133(1):41-50. doi: 10.1111/j.1365-2567.2011.03407.x. Epub 2011 Feb 16.
PMID: 21323661

Holmlund U, Amoudruz P, Johansson MA, Haileselassie Y, Ongoiba A, Kayentao K, Traoré B, Doumbo S, Schollin J, Doumbo O, Montgome
Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring.
Clin Exp Immunol. 2010 Dec;162(3):500-509. doi: 10.1111/j.1365-2249.2010.04275.x. Epub 2010 Oct 5.
PMID: 20942805 [PubMed - as supplied by publisher]

Sverremark-Ekström E.
Division of cytokines into TH1/TH2: a word of caution.
Reprod Sci. 2010 Apr;17(4):318-9. Epub 2010 Feb 18. No abstract available.
PMID: 20167744 [PubMed - indexed for MEDLINE]

Saghafian-Hedengren S, Sverremark-Ekström E, Linde A, Lilja G, Nilsson C.
Early-life EBV infection protects against persistent IgE sensitization.
J Allergy Clin Immunol. 2010 Feb;125(2):433-8. Epub 2009 Dec 5.
PMID: 19963258 [PubMed - indexed for MEDLINE]