Mattias Mannervik

Professor Mattias Mannervik

Stockholm University
The Wenner-Gren Institute
Developmental Biology
Svante Arrheniusväg 20B, room E331
106 91 Stockholm
Phone: 00 46 8 16 15 65
Fax: 00 46 8 61 26 127

Differential regulation of gene expression in time and space controls cell fate, differentiation and development. The Drosophila embryo constitutes a particularly well characterized system in terms of both the cis-regulatory sequences driving gene expression and the trans-acting factors involved in controlling transcription. This knowledge can be exploited to study mechanisms for regulating transcription that are used in vivo, with important implications for both normal development and disease. Our work concerns the role of chromatin regulators in epigenetic inheritance, and the function of chromatin regulators and other proteins as transcriptional co-regulators.

Selected publications

Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony R
A cis-regulatory map of the Drosophila genome.
Nature. 2011 Mar 24;471(7339):527-31.
PMID: 21430782

Qi D, Bergman M, Aihara H, Nibu Y, Mannervik M.
Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation.
EMBO J. 2008 Mar 19;27(6):898-909. Epub 2008 Feb 28.

Haecker A, Bergman M, Neupert C, Moussian B, Luschnig S, Aebi M, Mannervik M.
Wollknauel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase.
Development. 2008 May;135(10):1745-9. Epub 2008 Apr 9.

Haecker A, Qi D, Lilja T, Moussian B, Andrioli LP, Luschnig S, Mannervik M.
Drosophila Brakeless Interacts with Atrophin and Is Required for Tailless-Mediated Transcriptional Repression in Early Embryos.
PLoS Biol. 2007 May 15;5(6):e145 [Epub ahead of print]

Lilja T, Aihara H, Stabell M, Nibu Y, Mannervik M.
The acetyltransferase activity of Drosophila CBP is dispensable for regulation of the Dpp pathway in the early embryo.
Dev Biol. 2007 May 15;305(2):650-8. Epub 2007 Feb 7.



Cell Biology  Per Ljungdahl, Phone: +46 8 16 41 01

Developmental Biology Christos Samakovlis, Phone: + 46 8 16 15 64

Immunology Marita Troye Blomberg, Phone: + 46 8 16 41 64

Physiology Barbara Cannon, Phone:+ 46 8 16 41 20


Imaging Facility, IFSU

Zeiss LSM 780