Christos Samakovlis

Professor Christos Samakovlis

Stockholm University
The Wenner-Gren Institute
Developmental Biology
Svante Arrheniusväg 20B, room E353
106 91 Stockholm

Phone: 0046 8 16 15 64
Fax: 0046 8 61 26 127


Epithelial organogenesis in Drosophila
Branched tubular organs are found in most animals. They include tissues like the lung, kidney and the vascular system. Many of the basic principles of tube construction in these organs are conserved among species. We aim to describe the genetic programs leading to the formation of a functional epithelial tubular network. The Drosophila airways, the trachea, form a complex tubular system that delivers air directly to all tissues in the animal. Our work utilizes genetics, bioinformatics and live imaging in Drosophila to characterize the molecular control of tube size and epithelial organ maturation.

Selected publications

Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila.

Tiklová K, Senti KA, Wang S, Gräslund A, Samakovlis C.Nat Cell Biol. 2010 Nov;12(11):1071-7. Epub 2010 Oct 10.PMID: 20935638

The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins.

Wagner N, Weyhersmüller A, Blauth A, Schuhmann T, Heckmann M, Krohne G, Samakovlis C. Dev Biol. 2010 Mar 1;339(1):1-13. Epub 2009 Dec 28.

PMID: 20036230

The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila.

Wang S, Tsarouhas V, Xylourgidis N, Sabri N, Tiklová K, Nautiyal N, Gallio M, Samakovlis C. Nat Cell Biol. 2009 Jul;11(7):890-5. Epub 2009 Jun 14.

PMID: 19525935

Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. Sabri N, Roth P, Xylourgidis N, Sadeghifar F, Adler J, Samakovlis C. J Cell Biol. 2007 Aug 13;178(4):557-65. Epub 2007 Aug 6.

PMID: 17682050



Cell Biology  Per Ljungdahl, Phone: +46 8 16 41 01

Developmental Biology Christos Samakovlis, Phone: + 46 8 16 15 64

Immunology Marita Troye Blomberg, Phone: + 46 8 16 41 64

Physiology Barbara Cannon, Phone:+ 46 8 16 41 20


Imaging Facility, IFSU

Zeiss LSM 780