Eva Severinson

Professor Eva Severinson

Stockholm University
The Wenner-Gren Institute
Cell Biology
Svante Arrheniusväg 20B, room F 450/F 447
106 91 Stockholm
Sweden

Email: eva.severinson@wgi.su.se
Phone: 00 46 8 16 15 67
Fax:0046 8 15 98 37

Investigation of B lymphocytes: adhesion, motility and Ig class switching

In mammals, B lymphocytes produce antibodies to foreign antigens, such as virus, bacteria and fungus. When the body is exposed to such antigens, B cells respond by becoming activated to high-rate antibody secreting plasma cells. The immune reactions take place in the secondary lymphoid organs, for example lymph nodes and spleen. In these organs, B cells get signals by antigen, T cells and dendritic cells. Activated B cells form so-called germinal centres, consisting of rapidly proliferating cells.

Selected publications

Kis LL, Gerasimcik N, Salamon D, Persson EK, Nagy N, Klein G, Severinson E, Klein E.

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood. 2011 Jan 6;117(1):165-74. Epub 2010 Sep 27.
PMID: 20876453

Kis, L.L., Gerasimcik, N., Salamon, D. Persson, E.K., Nagy, N. Klein, G., Severinson, E. and Klein, E.
The STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood. 2011 Jan 6;117(1):165-74. Epub 2010 Sep 27.
PMID: 20876453

Severinson E.
When T cells cannot help.
Blood. 2010 Apr 29;115(17):3419-20. No abstract available.

Severinson E.
WASp stings mature lymphocytes.
Blood. 2008 Nov 15;112(10):3921-2. No abstract available.

Xiang Z, Cutler AJ, Brownlie RJ, Fairfax K, Lawlor KE, Severinson E, Walker EU, Manz RA, Tarlinton DM, Smith KG.
FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis.
Nat Immunol. 2007 Apr;8(4):419-29. Epub 2007 Feb 18.

 

Contacts

Cell Biology  Per Ljungdahl, Phone: +46 8 16 41 01

Developmental Biology Christos Samakovlis, Phone: + 46 8 16 15 64

Immunology Marita Troye Blomberg, Phone: + 46 8 16 41 64

Physiology Barbara Cannon, Phone:+ 46 8 16 41 20


 

Imaging Facility, IFSU

Zeiss LSM 780

Vacancies