Profiles

Elzbieta Glaser

Elzbieta Glaser

Professor

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Works at Department of Biochemistry and Biophysics
Telephone 08-16 24 57
Email elzbieta.glaser@dbb.su.se
Visiting address Svante Arrhenius väg 16
Room A 437
Postal address Institutionen för biokemi och biofysik 106 91 Stockholm

Research

Intracellular protein transport: signal peptides, molecular chaperones, proteolysis - connection to Alzheimer's disease.

Most of the mitochondrial and chloroplast proteins are nuclear encoded and synthesized as precursor proteins containing an N-terminal targeting peptide. After import, the targeting peptides are specifically cleaved off by the organellar processing peptidases. The cleaved targeting peptides are toxic to the organellar membranes and are rapidly degraded by a novel organellar peptidasome Presequence Protease (PreP), identified in our laboratory. We are using a combination of biochemical, molecular biological, biophysical and bioinformatic approaches to investigate different aspects of intracellular protein transport, such as sorting mechanisms, dual protein targeting, interaction of signal peptides with molecular chaperones and degradation of signal peptides by the PreP peptidasome. Furthermore, we are investigating the role of human mitochondrial PreP in Alzheimer´s disease as hPreP degrades amyloid-beta peptide forming insoluble fibers associated with Alzheimer´s disease.

 

Group members

Pedro Teixeira, Researcher

Beata Kmiec, Postdoc
 

 

Selected Recent Publications

 

Funding Sources

The Swedish Research Council (VR-NT); Alzheimersfonden; Carl Tryggers Foundation; Fundação para a Ciência e a Tecnologia, Portugal

Last updated: May 17, 2017

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