Profiles

Martin Ott

Martin Ott

Professor

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Works at Department of Biochemistry and Biophysics
Telephone 08-16 24 61
Email martin.ott@dbb.su.se
Visiting address Svante Arrhenius väg 16
Room A551
Postal address Institutionen för biokemi och biofysik 106 91 Stockholm

Research

Biogenesis of mitochondrially encoded proteins

Mitochondria allow our cells to use oxidative phosphorylation as a highly efficient way to generate ATP. The membrane-bound respiratory chain complexes are composed of proteins from two different genetic origins, namely the nuclear and the mitochondrial DNA. The research of our group is focused on the synthesis and assembly of the mitochondrially encoded proteins. Defects in the expression of mitochondrial genes can cause or influence many human diseases including cancer, aging and mitochondrial disorders. However, surprisingly little is known about the molecular mechanisms underlying the biogenesis of mitochondrially encoded proteins. We employ a large variety of biochemical, cell and molecular biology methods to gain mechanistic insights into this fundamental process.

We are always interested in qualified and motivated new co-workers. If you are interested in joining the group as undergraduate student for a Bachelor or a Master thesis, as PhD student or postdoc, please contact Martin Ott.

 

Group members

Anneli Borg, Postdoc

Lorena Marin, Postdoc

Abeer Singh, Postdoc

Hannah Dawitz, PhD Student

Mama Ndi, PhD Student

Magdalena Rzepka, PhD Student

Roger Salvatori, PhD Student

Katharina Stephan, PhD Student

Tamara Suhm, PhD Student

Alexandra Toth, PhD Student

Braulio Vargas Möller Hergt, PhD Student

 

Selected Publications

  • Kehrein K, Schilling R, Möller-Hergt BV, Wurm CA, Jakobs S, Lamkemeyer T, Langer T, Ott M. Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies.
    Cell Rep. 2015;10(6):843–853.
  • Heublein M, Burguillos MA, Vögtle FN, Teixeira PF, Imhof A, Meisinger C, Ott M. The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.
    Mol Biol Cell. 2014;25(21):3342-9.
  • Hildenbeutel M, Hegg EL, Stephan K, Gruschke S, Meunier B, Ott M.
    Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation.
    J Cell Biol. 2014;205(4):511-24.
  • Gruschke S, Römpler K, Hildenbeutel M, Kehrein K, Kühl I, Bonnefoy N, Ott M. The Cbp3-Cbp6 complex coordinates cytochrome b synthesis with bc1 complex assembly in yeast mitochondria.
    J Cell Biol. 2012;199(1):137-150.
  • Gruschke S, Kehrein K, Römpler K, Gröne K, Israel L, Imhof A, Herrmann JM, Ott M.Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly.
    J Cell Biol. 2011;193(6):1101-14.
 

Funding Sources

Swedish Research Council (VR-NT)

Carl Tryggers Foundation

Wenner-Gren Foundation

The Knut and Alice Wallenberg Foundation (KAW academy fellow)

Center for Biomembrane Research (CBR) at Stockholm University.

Last updated: May 16, 2017

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