Helicobacter pylori is a Gram-negative bacterium that colonizes the gastric mucosa of more than 50% of human population worldwide. Most infections are asymptomatic and once acquired, H. pylori can persist for the lifetime of the infected host. The infection is associated with high risk for the development of chronic gastritis, gastroduodenal ulcers and gastric cancer. A better understanding of bacterial pathogenesis is required for the development of strategies aimed at controlling infections. We are studying the events that lead to the disease development. Our aim is to identify the bacterial virulence factors and host immune responses that ultimately determine serious outcomes of the infection.

 

Keywords

Helicobacter pylori, virulence factors, bacterial pathogenesis, immun response

 

Selected publications

Pathak SK, Tavares R, de Klerk N, Spetz A-L, Jonsson A-B (2013)Helicobacter pylori Protein JHP0290 Binds to Multiple Cell Types and Induces Macrophage Apoptosis via Tumor Necrosis Factor (TNF)-Dependent and Independent Pathways. PLoS ONE 8(11): e77872.

Mohanram, V., Skold, A. E., Bachle, S. M., Pathak, S. K., & Spetz, A. L. (2013). IFN-alpha induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells. J Immunol. 190(7):3346-53

Pathak, S. K., Skold, A. E., Mohanram, V., Persson, C., Johansson, U., & Spetz, A. L. (2012). Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and beta2 integrins. J Biol Chem. 287(17):13731-42

Kumawat, K., Pathak, S. K., Spetz, A. L., Kundu, M., & Basu, J. (2010). Exogenous Nef is an inhibitor of Mycobacterium tuberculosis-induced tumor necrosis factor-alpha production and macrophage apoptosis. J Biol Chem. 285(17):12629-37

Kundu, M., Pathak, S. K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S., Noguchi, T., Takeda, K., Ichijo, H., Thien, C. B., Langdon, W. Y., & Basu, J. (2009). A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. Nat Immunol. 10(8):918-26

Basu, S., Pathak, S. K., Chatterjee, G., Pathak, S., Basu, J., & Kundu, M. (2008). Helicobacter pylori protein HP0175 transactivates epidermal growth factor receptor through TLR4 in gastric epithelial cells. J Biol Chem. 283(47):32369-76