Motility, adhesion and immunoglobulin class switching in B cells

B lymphocytes produce specific antibodies as a response pathogenic microorganisms. My research aims at understanding motility, adhesion and immunoglobulin class switching in B cells. I use mouse as a model system and I work both in vivo and in vitro.

 

Spreading of B lymphocytes as detected in scanning electron microscopy

 

Keywords

B lymphocytes, motility, adhesion, immunoglobulin class switching

Selected publications

Salamon, D., Adori, M., He, M., Bönefelt, P., Severinson, E., Kis, L.L., Ujvari, D., Leveau, N., Klein, G., & Klein, E.: (2012). Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: differential regulation in B cell lines derived from endemic and sporadic Burkitt’s lymphoma. Cytokine. 57, 360

Kis, L.L., Gerasimcik, N., Salamon, D. Persson, E.K., Nagy, N. Klein, G., Severinson, E. & Klein, E. (2011). The STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma. Blood. 117(1):165-74.

Severinson, E. (2010). When T cells cannot help. Blood. 115(17):3419-20. No abstract available

Severinson, E. (2008). WASp stings mature lymphocytes. Blood. 112(10):3921-2. No abstract available

Xiang, Z., Cutler, A.J., Brownlie, R.J., Fairfax, K., Lawlor, K.E., Severinson, E., Walker, E.U., Manz, R.A., Tarlinton, D.M., & Smith, K.G. (2007). FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol. 8(4):419-29.