Group Samakovlis

Group Christos Samakovlis

Epithelial organogenesis in Drosophila

Branched tubular organs are found in most animals. They include tissues like the lung, kidney and the vascular system. Many of the basic principles of tube construction in these organs are conserved among species. We aim to describe the genetic programs leading to the formation of a functional epithelial tubular network. The Drosophila airways, the trachea, form a complex tubular system that delivers air directly to all tissues in the animal. Our work utilizes genetics, bioinformatics and live imaging in Drosophila to characterize the molecular control of tube size and epithelial organ maturation.

Research project

Tube maturation: From morphogenesis to function

The development of air-filled respiratory organs is crucial for survival. We have combined live imaging with genetics to dissect airway maturation. Initially, a secretion burst deposits proteins into the nascent tracheal tubes. Solid material is then rapidly cleared and shortly thereafter liquid is removed from the lumen.

Research project

Grainy head in tube size control and wound healing

Grainy head (grh), is a phylogenetically conserved transcription factor. In grh mutants, the apical epithelial cell membrane is overgrown resulting in overgrown airway tubes.

Christos Samakovlis

 

Christos Samakovlis, Professor

Visiting address:
Svante Arrhenius väg 20C
Room E353

Postal address:
Stockholm University
Department of Molecular Biosciences,
The Wenner-Gren Institute
SE-106 91 Stockholm

Telephone: +46 8 16 1564
Fax: +46 8 16 4209
E-mail: christos.samakovlis@su.se

Group members

Enen Guo
Chie Hosono
Vasilios Tsarouhas
Hong-Phuong Nguyen
Ryo Matsuda
Alexandros Sountoulidis
Andreas Liontos
Dan Liu
Georgia Tsikala
Ana Pinheiro