Research projects

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Tube maturation: From morphogenesis to function

The development of air-filled respiratory organs is crucial for survival. We have combined live imaging with genetics to dissect airway maturation. Initially, a secretion burst deposits proteins into the nascent tracheal tubes. Solid material is then rapidly cleared and shortly thereafter liquid is removed from the lumen.

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Grainy head in tube size control and wound healing

Grainy head (grh), is a phylogenetically conserved transcription factor. In grh mutants, the apical epithelial cell membrane is overgrown resulting in overgrown airway tubes.

Christos Samakovlis

 

Christos Samakovlis, Professor

Visiting address:
Svante Arrhenius väg 20C
Room E353

Postal address:
Stockholm University
Department of Molecular Biosciences,
The Wenner-Gren Institute
SE-106 91 Stockholm

Telephone: +46 8 16 1564
Fax: +46 8 16 4209
E-mail: christos.samakovlis@su.se

Group members

Enen Guo
Chie Hosono
Vasilios Tsarouhas
Hong-Phuong Nguyen
Ryo Matsuda
Alexandros Sountoulidis
Andreas Liontos
Dan Liu
Georgia Tsikala
Elpidoforos Sakkas
Ana Pinheiro