Proteins carry out a wide range of important functions in our bodies. Knowledge about how they move around and through the crowded environments of our cells and tissues is key to understanding how they perform these crucial functions. Experiments exploring protein dynamics, however, often use samples that do not reflect the crowded and complex environments of the cell. At the European X-ray Free Electron laser (XFEL), scientists carried out X-ray photon correlation spectroscopy experiments to measure the nanoscopic structural dynamics of protein solution samples. The results, reported in Nature Communications open up the unique possibility of studying collective dynamics in protein solutions with high concentration, which is particularly interesting in the context of intracellular transport in eukaryotic cells and in drug design.
Capturing protein dynamics in crowded environments with the world’s brightest X-ray laser - Read the full article