Erik Sonnhammer

Erik Sonnhammer

Professor in Bioinformatics

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Works at Department of Biochemistry and Biophysics
Visiting address Science for Life Laboratory Karolinska Institutet Science Park,Tomtebodavägen 23A,17165 Solna.
Room A2421
Postal address Institutionen för biokemi och biofysik 106 91 Stockholm


Protein Function Prediction with Bioinformatics Approaches

The DNA sequence of the human genome is now known, yet we are only starting to understand the functional networks of the proteins encoded in it. The group is addressing this issue with a number of computational approaches, including hidden Markov models, Bayesian networks, clustering algorithms, evolutionary models, and discriminant statistical methods. The goal is to predict function both in terms of biochemical activity and role in a pathway. To predict pathway interactions we are developing integrative computational methods and databases with a focus on identifying new disease genes. The resulting networks are available at


Group members

Davide Buzzao, PhD student

Miguel Castresana, PhD student

Thomas Hillerton, PhD student

Emma Persson, PhD student

Deniz Secilmis, PhD student

Erik Zhivkoplias, PhD student


Selected Publications

  • "Global networks of functional coupling in eukaryotes from comprehensive data integration"
    Andrey Alexeyenko and Erik L.L. Sonnhammer
    Genome Research, 19:1107-1116 (2009)

  • "Network-based identification of novel cancer genes"
    Gabriel Östlund, Mats Lindskog, and Erik L.L. Sonnhammer
    Molecular and Cellular Proteomics, 9:648-655 (2010)



Funding Sources

Swedish Research Council

Last updated: November 11, 2020

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