Hui Xin Wang


Visa sidan på svenska
Telephone 08-553 789 18
Visiting address Frescati Hagväg 16A
Postal address Stressforskningsinstitutet 106 91 Stockholm

About me

My major research field is epidemiology of neurodegenerative diseases in the elderly and of cardiovascular disease in middle age. My specific research interests are: (1) influence of lifestyle (smoking, vitamin B12 and folate, social network, and leisure activities) and psychosocial factors (personality, work stress, life-course cognitive reserve enhancing factors) and their interactions with genetic factors on risk of dementia, cognitive decline, metabolic health, depression and mortality; and (2) impact of psychosocial factors (social support, work stress, and depressive symptoms) on progression of coronary heart disease.


Selected publications

Wang H-X, MacDonald S.W.S. Dekhtyar S, Fratiglioni L. Association of life-long exposure to cognitive reserve-enhancing factors with dementia risk. PLOS Med. March 14, 2017.

Rizzuto D, Mossello E, Fratiglioni L, Santoni G, Wang H-X. Personality and survival in older age: the role of lifestyle and health status. Am J Geriatri Psychiatry. DOI:

Pan K-Y*, Xu W, Mangialasche M, Fratiglioni L, Wang H-X*. Work-related psychosocial stress and the risk of type 2 diabetes. J Intern Med. 2017 Apr 24. 281(6):601-610.

Gerritsen L, Kalpouzos G, Westman E, Simmons A, Wahlund L-O, Bäckman L, Fratiglioni L, Wang H-X. The influence of negative life events on hippocampal and amygdala volumes in old age: A life-course perspective. Psychol Med. 2015 Apr;45(6):1219-28.

Hahn EA, Wang H-X*, Andel R, Fratiglioni L. A Change in Sleep Pattern May Predict Alzheimer’s disease. Am J Geriatr Psychiatry. 2014 Nov;22(11):1262-71.

Wang H-X, Jin Y, Hendrie HC, Liang C, Yang L, Cheng Y, Unverzagt FW, Ma F, Hall HS, Murrell JR, Li P, Bian J, Pei J-J, Gao S. Late life leisure activities and risk of cognitive decline. J Gerontol A Biol Sci Med Sci. 2013;68(2):205-13

Wang H-X, Gustafson D, Kivipelto M, Pedersen N.L., Skoog I, Windblad B, Fratiglioni L. Education halves the risk of dementia due to apolipoprotein ε4 allele. Neurol Aging 2012;33(5):1007.e1-7.

Wang H-X, Wahlberg M, Karp A, Winblad B, Fratiglioni L. Psychosocial stress at work is associated with increased dementia risk in late life. Alzheimer’s & Dementia 2012;8:114-120.

Rydwik E, Welmer A-K, Angleman S, Fratiglioni L, Wang H-X. Is midlife occupational physical activity related to disability in old age? PLoS ONE 2013;8(7):e70471. doi: 10.1371/journal.pone.0070471

Paillard-Borg S, Fratiglioni L, Xu W, Winblad B, Wang H-X. An active lifestyle postpones dementia onset by more than one year in very old adutls. J Alzheimers Dis. 2012;31(4):835-42.

Wang H-X, Karp A, Herlitz A, Crowe M, Kåreholt I, Winblad B, Fratiglioni L. Personality and lifestyle in relation to dementia incidence. Neurology 2009;72:253-259.

Wang H-X, Mittleman MA, Leineweber C, Orth-Gomer K. Depressive symptoms in combination with social isolation hastens progression of coronary artery atherosclerosis in middle-aged women.Psychother Psychosom 2006:75;96-102.

Wang H-X, Mittleman MA, Orth-Gomer K. Influence of social support on progression of coronary artery disease in women. Soc Sci Med 2005;60:599-607.

Wang H-X, Karp A, Winblad B, Fratiglioni L. Late-life engagement in social and leisure activities is associated with a decreased risk of dementia. Am J Epidemiol 2002;155:1081-7.

Wang H-X, Wahlin Å, Basun H, Fastbom J, Winblad B, Fratiglioni L. Low levels of vitamin B12 and folate and Alzheimer’s disease incidence. Neurology 2001;56:1188-94.

Fratiglioni L, Wang H-X, Maytan M, Ericsson K, Winblad B. The Influence of Social Network on the Occurrence of Dementia. Lancet 2000;355:1315-9.

Wang H-X, Fratiglioni L, Frisoni GB, Viitanen M, Winblad B. Smoking and the occurrence of Alzheimer’s disease. Am J Epidemiol1999;149:640-4.

Last updated: March 15, 2019

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