Amyotrophic lateral sclerosis (ALS) is a severe disease of the nervous system in which motor neurons, the neurons which control our muscles, gradually stop working. Motor neurons act as the link between the brain and the muscles, allowing us to move consciously and voluntarily. When this connection breaks down, muscles can no longer be controlled properly, which leads to stiffness, weakness, spastics and eventually paralysis.

ALS is a very complex disease. More than 40 genes have already been associated to it and many more are likely involved. It is defined by multiple different combinations of causes and different disease progressions. This is what makes it especially difficult to find a treatment and at present, there is no cure. However, a few treatments are available which can slow the course of the disease slightly.

My doctoral research project focuses on understanding how mutations in genes associated with ALS affect motor neurons and muscles. To this end, I study their metabolism, i.e. the way they produce and use energy and the role of mitochondria, the powerhouses of our cells. I am especially interested in what happens at the earliest stages of the disease, even before symptoms appear. By investigating when and how motor neurons and muscles begin to fail in ALS, I hope to contribute to new ways of protecting and supporting them, to keep them functional for as long as possible.