Profiles

Sifang Liao

Doktorand

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Works at Department of Zoology
Telephone 08-16 40 87
Email sifang.liao@zoologi.su.se
Visiting address Svante Arrheniusväg 18 B
Room D 421
Postal address Zoologiska institutionen: Funktionell zoomorfologi 106 91 Stockholm

Publications

A selection from Stockholm University publication database
  • Yiting Liu (et al.).
  • 2016. Yiting Liu (et al.). Scientific Reports 6

    The insulin/insulin-like growth factor signaling pathway is evolutionarily conserved in animals, and is part of nutrient-sensing mechanisms that control growth, metabolism, reproduction, stress responses, and lifespan. In Drosophila, eight insulin-like peptides (DILP1-8) are known, six of which have been investigated in some detail, whereas expression and functions of DILP1 and DILP4 remain enigmatic. Here we demonstrate that dilp1/DILP1 is transiently expressed in brain insulin producing cells (IPCs) from early pupa until a few days of adult life. However, in adult female flies where diapause is triggered by low temperature and short days, within a time window 0-10h post-eclosion, the dilp1/DILP1 expression remains high for at least 9 weeks. The dilp1 mRNA level is increased in dilp2, 3, 5 and dilp6 mutant flies, indicating feedback regulation. Furthermore, the DILP1 expression in IPCs is regulated by short neuropeptide F, juvenile hormone and presence of larval adipocytes. Male dilp1 mutant flies display increased lifespan and reduced starvation resistance, whereas in female dilp1 mutants oviposition is reduced. Thus, DILP1 is expressed in non-feeding stages and in diapausing flies, is under feedback regulation and appears to play sex-specific functional roles.

Show all publications by Sifang Liao at Stockholm University

Last updated: June 5, 2018

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