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Ville Kaila

Professor in Biochemistry

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Works at Department of Biochemistry and Biophysics
Telephone 08-16 42 40
Email ville.kaila@dbb.su.se
Visiting address Svante Arrhenius väg 16
Postal address Institutionen för biokemi och biofysik 106 91 Stockholm

About me

2019- Full Professor/Chair of Biochemistry, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

2018-2019 Professor (W3) of Computational Biocatalysis, Department of Chemistry, Technical University Munich (TUM), Munich, Germany.

2013-2018 Tenure-track Professor (W2 to W3) of Computational Biocatalysis, Department of Chemistry, Technical University Munich (TUM), Munich, Germany.

2013 Offer for Assistant Professor (W1) at the Department of Chemistry and Biochemistry, Free University Berlin, Germany (declined).

2011 Title of Docent (Adjunct Professor) of Physical Biochemistry, University of Helsinki.

2010-2013 Post-doctoral researcher, National Institutes of Health (NIH), Bethesda, MD, USA.

2010-2012 EMBO Long-Term Fellow.

2009 Ph.D. in Biochemistry, University of Helsinki, Finland.

2006 M.Sc. in Biochemistry (Extended minors in Physical Chemistry and Theoretical Physics), University of Helsinki, Finland.

1994-2004 Training for a solo violin career, Sibelius Academy, Finland.

 

Research

Deciphering molecular mechanisms in enzyme catalysis and biological energy transduction

Our research is focused on understanding molecular principles of enzyme catalysis, with special emphasis on biological energy conversion machinery involved in cell respiration and photosynthesis. To this end we develop state-of-the-art methodology of computational biochemistry in combination with biochemical and biophysical experiments to obtain insight in the structure, function, and dynamics of these fascinating biomolecules. 

See the description of our Knut and Alice Wallenberg (KAW/WAF) project here .

 

Group members

Dr. Ana P. Gamiz-Hernadez, staff scientist
Dr. Grant Kemp, researcher
Dr. Dirk Auman, postdoc
Dr. Patricia Saura Martinez, postdoc
Dr. Sophie Mader, postdoc
Friederike Allgöwer, PhD student
Mona Baumgart, PhD student (TUM)
Alexander Jussupow, PhD student (TUM/SU)
Hyunho Kim, PhD student
Max Mühlbauer, PhD student (TUM/SU)
Max Pöverlein, PhD student
Daniel Riepl, PhD student
Louis Cochen, PhD student
Michael Röpke, PhD student (TUM)
Daniel Frey, MSc student (TUM/SU)
Eric Hartmann, MSc student (TUM/SU)

Selected Publications

  • Jussupow A, Di Luca A, Kaila VRI (2019) How cardiolipin modulates the activity of complex I. Science Adv 5, eaav1850.
  • Warnau J, Sharma V, Gamiz-Hernandez AP, Di Luca A, Haapanen O, Vattulainen I, Wikström M, Hummer G, Kaila VRI (2018) Redox-Coupled Quinone Dynamics in the Respiratory Complex I. PNAS 115: E8413-E8420.
  • Mader SL, Bräuer A, Groll M, Kaila VRI (2018) Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ. Nature Comm 9, 1168:1-8.
  • Supekar S, Kaila VRI (2018) Activation dynamics of the K-channel in cytochrome c oxidase. Chem Science 9:6703-6710.
  • Gamiz-Hernandez AP, Jussupow A, Johansson MP, Kaila VRI (2017) Terminal Electron-Proton Transfer Dynamics coupled to Quinone reduction in Respiratory Complex I. JACS 139:16282-16288.
  • Suomivuori C-M, Gamiz-Hernandez AP, Sundholm D, Kaila VRI (2017) Energetics and dynamics of a light-driven sodium-pumping rhodopsin. PNAS 114:7043-7048.
  • Di Luca A, Gamiz-Hernandez AP, Kaila VRI (2017) Symmetry related proton transfer pathways in respiratory Complex I. PNAS 114:E6314-E6321.
  • Sharma V, Belevich G, Gamiz-Hernandez AP, Róg T, Vattulainen I, Wikström M, Hummer G, Kaila VRI (2015) Redox-Induced Activation of the Proton Pump in the Respiratory Complex I. PNAS 112:11571-11576.
  • Supekar S, Gamiz-Hernandez AP, Kaila VRI (2016) A Protonated Water Cluster as a Transient Proton Loading Site in Cytochrome c Oxidase. Angew Chemie Intl Ed 55:11940-11944.
  • Kaila VRI, Wikström M, Hummer G (2014) Electrostatics, Hydration, and Proton Transfer Dynamics in the Membrane Domain of Respiratory Complex I. PNAS 111:6988-6993.
  • Kaila VRI, Schotte F, Hyun S-C, Hummer G, Anfinrud PA (2014) Reconciling contradictions in time-resolved x-ray structures of early intermediates in the photocycle of photoactive yellow protein. Nature Chem 6:258-259.

Show all publications by Ville R. I. Kaila
Check our latest publications here:
https://villekaila.wordpress.com/publications/

Last updated: January 11, 2021

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