Research group Marta Carroni's research group

In our group, we use mainly cryo-EM to discover molecular regulatory mechanisms. We combine the technique also with cryogenic electron tomography (cryo-ET) and work at developing combinatory methods with fluorescence microscopy. We follow two main lines of research.

In the first one, we aim at understing the molecular mechanics of AAA+ proteins involved in cellular protein quality control. AAA+ are fascinating systems as they  can perform extremely different tasks in the cell while sharing the same basic structural fold. We look into the special structural inserts and interaction with adaptor proteins that confer AAA+ chaperones resistance to stress in both bacteria and humans. 

In a second line of research we use cryo-EM as a tool for longitudinal epitope mapping of antibody response in animal models and humans with the aim of gaining insights useful for better vaccine design or for understanding autoimmune diseases. 

The group works in close proximity to the cryo-EM national unit at SciLifeLab, which I also supervise.

There are no research project connections.

Department of Biochemistry and Biophysics

New instrument at SciLifeLab reduces common cryo-EM problem

The long-term problem in cryo-EM about insufficient data due to uneven protein molecules distribution can now be reduced thanks to a new instrument for specimen preparation of cryo-EM grids, the Chameleon.

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