Research group Group Riedel
Aging is a strong determinant of human health and longevity. We study the molecular mechanisms that regulate aging, aiming to eventually target them for therapeutic purposes.
Our health and longevity is largely determined by the rate at which we age. Fortunately, ageing is a plastic process. In our research group we use the nematode Caenorhabditis Elegans as a model system to understand the pathways that can accelerate or slow aging. C. Elegans is ideal for ageing-related research, as it is technically well established, short-lived (allowing for lifespan as an easily measurable phenotype), and very responsive to alterations in its ageing-regulatory pathways. These studies are complemented by efforts in human tissue culture, to verify human conservation and further explore our findings for therapeutic purposes. Finally, we are developing and applying screening approaches to identify aging-preventive compounds that have a high probability of working in humans.
Our research combines biochemistry (Proteomics, ChIP-Seq, mRNA-Seq, ATAC-Seq,…) with high-throughput bioinformatic, genetic, and pharmacological screening approaches, to understand the regulation of aging at molecular and mechanistic resolution and to identify aging-preventive interventions.
We thank our current funding sources: Vetenskapsrådet, Cancerfonden, Novo Nordisk Fonden, the National Institutes of Health, and Impetus Grants.
Group members
Group managers
Christian Riedel
Associate Professor
Members
Patryk Marcinkowski
PhD student
Andrea Mosqueda Solis
Postdoc