Stockholm university

Research group Group Riedel

Aging is a strong determinant of human health and longevity. We study the molecular mechanisms that regulate aging, aiming to eventually target them for therapeutic purposes.

C_Riedel_bild
C. elegans expressing a GFP-tagged version of the aging-preventive transcription factor DAF-16/FOXO. Copyright: Christian Riedel.

Our health and longevity is largely determined by the rate at which we age. Fortunately, ageing is a plastic process. In our research group we use the nematode Caenorhabditis Elegans as a model system to understand the pathways that can accelerate or slow aging. C. Elegans is ideal for ageing-related research, as it is technically well established, short-lived (allowing for lifespan as an easily measurable phenotype), and very responsive to alterations in its ageing-regulatory pathways. These studies are complemented by efforts in human tissue culture, to verify human conservation and further explore our findings for therapeutic purposes. Finally, we are developing and applying screening approaches to identify aging-preventive compounds that have a high probability of working in humans.

Our research combines biochemistry (Proteomics, ChIP-Seq, mRNA-Seq, ATAC-Seq,…) with high-throughput bioinformatic, genetic, and pharmacological screening approaches, to understand the regulation of aging at molecular and mechanistic resolution and to identify aging-preventive interventions.

We thank our current funding sources: Vetenskapsrådet, Cancerfonden, Novo Nordisk Fonden, the National Institutes of Health, and Impetus Grants.

Group members

Group managers

Christian Riedel

Associate Professor

Department of Molecular Biosciences, The Wenner-Gren Institute

Members

Alan Kavsek

Postdoc

Department of Medicine, Karolinska Institutet

Patryk Marcinkowski

PhD student

Department of Medicine, Karolinska Institutet

Andrea Mosqueda Solis

Postdoc

Department of Medicine, Karolinska Institutet

Jérôme Salignon

Resarcher

Department of Medicine, Karolinska Institutet

Publications