The course covers the molecular mechanisms regulating the division and differentiation of stem cells in development and cancer. Mechanisms of cell differentiation and de-differentiation, reprogramming, induction of pluripotent cells, and the signaling pathways controlling these processes will be discussed. Important aspects of stem cell regulation, such as epigenetic changes, the presence of a niche, and asymmetric cell division will be covered. Medical applications, mainly stem cell therapy and consequences of the cancer stem cell concept for cancer treatment, will be discussed. Course period: January - March
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