This course introduces the principles of toxicology with the aim of understanding the hazards posed to humans and wildlife by chemical contaminants. A particular focus for this course will be on dose-response relationships, how chemicals are taken up, distributed and eliminated in living organisms, subsequent adverse effects, and consideration of underlying molecular mechanisms of toxicity.
Topics covered include:
* exploration of dose-response relationships, toxicological thresholds and methods in toxicological testing
* chemical and biological considerations of absorption, distribution, metabolism and excretion (ADME)
* toxicological receptors, and mechanisms-of-action leading to adverse-effects
Course includes lectures, laboratory work, workshop exercises, presentations and discussions.