SR Sveriges Radio - Vetenskapsradion

"Nytt spår i jakten på vaccin mot malaria" (klicka på länken för att lyssna på klippet)

The Fulani, living in West Africa, are more protected against malaria as reflected by lower parasitemias and less clinical symptoms than other ethnic groups living under similar socioeconomic conditions.  The Fulani have lower frequencies of the classical malaria resistance genes, like those coding for sickle cell anemia, thalassaemias and G6PD deficiency. Conventional genetics using single cell nucleotide polymorphism analysis did not provide any clues to why they are more protected. The Fulani are nomads and cattle breeders which could affect their epigenetic profile which might  influence the stronger inflammatory responses seen in the Fulani. A better knowledge of this could improve the existing vaccines perhaps by adding in a substance that could induce inflammation.


SR Sveriges Radio - Vetandets värld

"Kampen mot malaria" (Klicka på länken för att lyssna på programmet)


The Plasmodium falciparum parasite has started to become resistance the effective anti-malarial drug artemisin. If this resistance will continue this will lead to a catastrophic situation for people living in malaria endemic countries, since no other efficient treatments are available. To control for the development of resistance it is very important to follow the known genetic resistance markers in the mosquito. When we find such markers we need to stop the parasite at all levels, by improving vaccines and anti-malaria drugs, distribute impregnated bednets and bed curtains, develop tools to eliminate the mosquito larvae, drain areas so that the mosquito cannot lay eggs, possibly genetically modify the mosquite so that they cannot not transmit the parasite.

Anders Björkman and Marita Troye-Blomberg are discussing alternative ways to protect people against malaria.