Refereed articles

Steinz, M.M., Persson, M., Aresh, B., Olsson, K., Cheng, A.J., Ahlstrand, E., Lilja, M., Lundberg, T.R., Rullman, E., Ängeby Möller, K., Sandor, K., Ajeganova, S., Yamada, T., Beard, N., Karlsson, B.C., Tavi, P., Kenne, E., Svwensson, C.I., Rassier, D.E., Karlsson, R., Friedman, R., Gustafsson, T., Lanner, J.T. (2019) Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis. JCI Insight 2019 Mar 28;5. pii: 126347. doi: 10.1172/jci.insight.126347.

Nejedla M., Li, Z., Masser, A.E., Biancospino, M., Spiess, M., Mackowiak, S.D., Friedländer, M.R., and Karlsson, R. (2017) A Fluorophore Fusion Construct of Human Profilin I with Non-Compromised Poly(LProline)Binding Capacity Suitable for Imaging, J. Mol. Biol.

Wen P., Grenklo, S., Arpino, G., Tan, X., Liao, H-S., Heureaux, J., Peng, S-Y., Chiang, H-C., Hamid, E., Zhao, W-D., Shin, W., Näreoja, T., Evergren, E., Jin, Y., Karlsson, R., Ebert, S., Jin, A., Liu, A., Shupliakov, O., and Wu L-G (2016) Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane. Nature communications DOI: 10.1038/ncomms12604.

Nejedla, M., Sara, S., Sulimenko, V., de Almeida, FN., Blom, H., Draber, P., Aspenström, P., Karlsson, R. (2016) Profilin connects Actin Assembly with Mictrotubule dynamics. Mol Biol Cell. pii: mbc.E15-11-0799. [Epub ahead of print]

Spiess, M., Echbarthi, M., Svanström, A., Karlsson, R., Grantham, J. (2015) Over-expression Analysis of all eight subunits of the molecular chaperone CCT in mammalian cells reveals a novel function for CCTdelta. J Mol Biol. doi: 10.1016/j.jmb.2015.06.007. [Epub ahead of print]

Elliott, KL., Svanström, A., Spiess, M., Karlsson, R., Grantham, J. (2015) A novel function of the monomeric CCTepsilon subunit connects the Serum Response Factor pathway to chaperone-mediated actin folding Mol Biol Cell E15-01-0048

Packham, S., Warsito, D., Lin, Sadi, S., Karlsson, R., Sehat, B., and Larsson O. (2015) Nuclear translocation of IGF-1R via p150Glued and an importin-β/RanBP2-dependent pathway in cancer cells. Oncogene 34:2227–2238

Johnsson, A-K., and Karlsson, R. (2011) Synaptotagmin I causes phosphatidylinositol lipid-dependent actin remodeling in cultured non-neuronal and neuronal cells. Exp Cell Res 318:114-26.

Lassing, I., Hillberg, L., Höglund, A-S., Karlsson R., Schutt, C., and Lindberg U. (2010) Tropomyosin is a tetramer under physiological salt conditions. Cytoskeleton, 67:599–607

Johnsson, A-K., and Karlsson, R. (2010) Microtubule-dependent localization of profilin ImRNA to actin polymerization sites in serum-stimulated cells. Eur J Cell Biol 89:394-401.

Yamamoto, D., Csikasz, R., Li, Y., Sharma, G., Hjort, K., Karlsson, R., and Bengtsson, T. (2008) Myotube formation on micro-patterned glass: a new experimental system for studies of muscle differentiation in vitro. J Histochem & Cytochem 56:881-92.

Yu, L., Grenklo, S., and Karlsson, R. (2008) The Profilin:Actin complex localizes to sites of dynamic actin polymerization at the leading edge of migrating cells and pathogen induced actin tails. Eur J Cell Biol 87:893-90.

Marushchak, D., Grenklo, S., Johansson, T., Karlsson, R. and Johansson, L.B-Å. (2007) Fluorescence depolarization studies of filamentous actin analyzed with a genetic algorithm. Biophys J. 93:3291-3299

Boukhelifa, M., Moza, M., Johansson, T., Rachlin, A., Parast, A., Mykkanen, O.M., Roy, P., Jockusch, B.M., Carpen, O., Karlsson, R., and Otey C.A. (2006) The proline-rich protein palladin is a binding partner for profilin. FEBS Journal. 273:26-33

Johansson, T., Grenklo, S., and Karlsson, R. (2004) Detection of Binding Partners to the Profilin:actin Complex by Far western and Mass Spectrometry analyses. Analytical Biochem. 335:228-234.

Grenklo, S., Johansson, T., Bertilson, L., and Karlsson, R. (2004) Actin antibodies generated against profilin:actin distinguish between non-filamentous and filamentous actin, and label cultured cells in a dotted pattern. Eur J Cell Biol. 83:413-423.

Grenklo, S., Geese, M., Lindberg, U., Wehland, J., Karlsson, R. and Sechi, A. (2003) Critical role for profilin:actin in the intracellular motility of Listeria monocytogenes. EMBO Reports 4:523-529.

Skare,P., Kreivi, J.P., Bergström, Å., and Karlsson, R. (2003) Profilin I colocalizes with speckles and Cajal bodies; a possible role in pre-mRNA splicing. Exp. Cell Research. 286:12-21.

Skare, P., and Karlsson, R. (2002) Evidence for two interaction regions for phosphatidylinositiol (4,5)-bisphosphate on mammalian profilin I. FEBS Lett 522:119-124.

Nyman, T., Schűler, H., Korenbaum, E.,  Schutt, C.E., Karlsson R., and Lindberg, U. (2002) The role of MeH73 in actin polymerization and ATP hydrolysis. J Mol Biol 317:577-589.

Nyman, T., Page, R., Schutt, C.E., Karlsson R., and Lindberg, U. (2002) A crosss-linked profilin:actin heterodimer interferes with elongation at the fast-growing end of F-actin. J Biol Chem. 277:15828-15833

Schűler, H., Schutt, C.E., Lindberg, U., and Karlsson R. (2000) Covalent binding of ATPγS to the nucleotide-binding site in S14C-actin. FEBS Letters 476:155-159.

Schűler, H., Nyåkern, M., Schutt, C.E., Lindberg, U., Karlsson, R. (2000) Mutational analysis of arginine 177 in the nucleotide-binding site of ß-actin. Eur J Biochem. 267:4054-4062.

Hájková, L., Nyman, T., Lindberg, U., and Karlsson R. (2000) Effects of cross-linked profilin:ß/γ-actin on the dynamics of the microfilament system in cultured cells Exp Cell Res. 256:112-121.

Schűler, H., Lindberg, U., Schutt, C.E., and Karlsson R. (2000) Thermal unfolding of G-actin monitored with the DNase I-inhibition assay: stabilities of actin isoforms. Eur J Biochem. 267:476-486.

Hooshmand-Rad, R., Hájková, L., Klint, P., Karlsson, R., Vanhaesebroeck, B., Claesson-Welsh, L., and Heldin, C-H. (2000) The PI 3-K isoforms p110 and p110 have differential roles in PDGF and insulin-mediated signaling. J Cell Sci. 113:207-14

Schűler, H., Korenbaum, E., Schutt, C.E., Lindberg, U., and Karlsson R. (1999) Mutational analysis of residues serine 14 and aspartic acid 157 in the nucleotide-binding site of ß-actin. Eur J Biochem 265:210-220 [publishers errata ibid 266:697, 1999].

Korenbaum, E., Nordberg,P., Björkegren-Sjögren, C., Schutt, C.E., Lindberg,U. and Karlsson, R. (1998) The role of profilin in actin polymerization and nucleotide exchange. Biochemistry 37:9274-9283.

Björkegren-Sjögren, C., Korenbaum, E., Nordberg,P., Lindberg, U., and Karlsson, R. (1997) Isolation and characterization of two profilin mutants unable to bind poly(L-proline). FEBS Letters 418:258-264.

Hájková, L., Björkegren-Sjögren, C., Korenbaum, E., Nordberg,P., and Karlsson, R. (1997) Characterization of a mutant profilin with reduced actin-binding capacity: effects in vitro and in vivo. Exp Cell Res. 234:66-77.

Weeds, A.G., Gooch, J., McLaughlin, P., Bentsdotter, M and Karlsson, R. (1995) Identification of the trapped calcium in the gelsolin segment 1:actin complex: implications for the role of calcium in the control of gelsolin activity. FEBS Letters, 360:227-230.

13. Björkegren, C., Rozycki, M., Schutt, C.E., Lindberg, U. and Karlsson, R. (1993) Mutagenesis of human profilin locates its poly(L-proline)-binding site to a hydrophobic patch of aromatic amino acids. FEBS Letters 333:123-126.

Aspenström, P., Schutt, C.E., Lindberg, U. and Karlsson, R. (1993) Mutations in -actin. Influence on polymer formation and on interactions with myosin and profilin. FEBS Lett 329:163-170.

Aspenström, P., Lindberg, U. and Karlsson, R. (1992) Site-specific amino-terminal mutants of yeast-expressed -actin. Characterization of the interaction with myosin and tropomyosin. FEBS Lett 303:59-63.

Aspenström, P., Engkvist, H., Lindberg, U. and Karlsson, R. (1992) Characterization of yeast expressed -actins site-specifically mutated at the tumor-related residue Gly245. Eur J Biochem. 207:315-320.

Aspenström, P. and Karlsson, R. (1991) Interference with myosin subfragment-1(S1) binding by site directed mutagenesis of actin. Eur J Biochem. 200:35-41.

Karlsson, R., Aspenström, P. and Byström, S.A. (1991) A chicken b-actin gene can complement a disruption of the Saccharomyces cerevisiae ACT1 gene. Mol Cell Biol. 11:213-217.

Aspenström, P., Lassing, I. and Karlsson, R. (1991) Production, isolation and characterization of human profilin from Saccharomyces cerevisiae. J Muscle Res & Cell Motility. 12:201-217.

Karlsson, R. (1988) Expression of chicken /γ-actin in Saccharomyces cerevisiae. Gene 68:249-257.

Reinach, F.C. and Karlsson, R. (1988) Cloning, expression and site-specific mutagenesis of chicken skeletal muscle troponin C. J Biol Chem. 263:2371-2376.

Karlsson, R. and Lindberg, U. (1985) Changes in the organization of actin and myosin in non-muscle cells induced by N-ethyl-maleimide. Exp Cell Res. 157:95-115.

Karlsson, R., Lassing, I., Höglund, A.-S. and Lindberg, U. (1984) The organization of microfilaments in spreading platelets: a comparison with fibroblasts and glial cells. J Cell Physiol. 121:96-113.

Lindberg, U., Höglund, A.-S. and Karlsson, R. (1981) On the ultrastuctural organization  of the microfilament system and the possible role of profilactin. Biochimie. 63:307-23.

Höglund,  A.-S., Karlsson, R., Arro, E., Fredriksson, B.-A. and Lindberg, U. (1980) Visualization of the peripheral weave of microfilaments in glial cells. J Muscle Res & Cell Motility. 1:127-146.


Reviews and Book Chapters

Grantham, J., Lassing, I., and Karlsson R (2012) Controlling the cortical actin motor. Protoplasma 269:1001-1015.

Lindberg, U., Karlsson, R., Lassing, I., Schutt, CE, Höglund, AS (2008) The microfilament system and malignancy. Sem in Cancer Biol. 18:2-11.

Lindberg, U. and Karlsson, R. (2008) Actin is where it’s at. Semin in Cancer Biol. 18:1 (Editorial comment).

Karlsson R. and Lindberg, U. (2006) Profilin, an essential control element for actin polymerization. In Actin Monomer-binding Proteins. Editor: Pekka Lappalainen, Landes Bioscience, Georgetown, USA.

Schűler, H., Karlsson R., Schutt, C.E., and Lindberg, U. (2006) The connection between actin ATPase and polymerization. In Advances in Molecular and Cellular Biology, vol

Schűler, H., Korenbaum, E., Schutt, C.E., Lindberg, U., and Karlsson R. (1997) Studies of the ATP-binding site of actin using site-directed mutagenesis. In Interacting protein domains – Their role in signal and energy transduction. Editor, Ludwig Heilmeyer, Springer Verlag, Berlin.



Wang YL., Burridge K., Dembo M., Gabbiani G., Hanks SK., Hosoya, H., Janmey P., Karlsson R., Lindberg U., Mabuchi I., Otey C., Rottner K., Small JV., Wang CL., Zigmond S. (2004) Science 303:1974-6.