Henrietta Nielsen Universitetslektor

Henrietta M Nielsen, PhD
Lektor i neurokemi och molekylär neurobiologi
Senior Editor Molecular Neurodegeneration
Associate Editor Jounal of Alzheimer's Disease
Academic Editor PLOS One
Editorial Board member, Aging Brain
President of the International Society for Molecular Neurodegeneration (ISMND)

UTBILDNING

2000-2003
Lunds Universitet, Sverige
Leg. Biomedicinsk Analytiker

2003-2004
Kalmar Högskola, Sverige
Magisterexamen i biomedicin

2004-2007
Lunds Universitet, Sverige
Filosofie doktorsexamen i medicinska vetenskaper

TIDIGARE ANSTÄLLNINGAR

2002-2004
Blodcentralen, Skånes Universitetssjukhus i Lund, Sverige
Laboratorieassistent/BMA                                                              

2008-2009
VU University Medical Center, Amsterdam, the Netherlands     
Postdoc

2009-2012   
Luns Universitet, Institutionen för kliniska vetenskaper Malmö, Sverige
Biträdande forskare, postdoktor

2012-2014
Mayo Clinic, Jacksonville FL, USA
Research Associate/Instructor of neuroscience

2014-2015
Mayo Clinic, Jacksonville FL, USA
Assistant Professor of Neuroscience         

ADMINISTRATIVA UPPDRAG   

Förtroendevalda uppdrag

2002
Lunds Universitet, Lund, Sverige
Studeranderepresentant i styrelsen för Biomedicinska Analytikerprogrammet

2005-2007
Lunds Universitet, Lund, Sverige
Styrelseledamot i Doktorandkåren

2009-2010
Lunds Universitet, Lund, Sverige
Grundare av och styrelsemedlem LPS, Lund Postdoctoral Society

2010-2011
Lunds Universitet, Medicinska fakulteten, Lund, Sverige
Future Faculty projektadministratör

2018-2022
Stockholms Universitet, Stockholm, Sverige
Lärarrepresentant i institutionsstyrelsen Biokemi och Biofysik

2018-2020
Stockholms Universitet, Stockholm, Sverige
Experimental Core Facility styrkommittémedlem

2022-2023
Stockholms Universitet, Stockholm, Sverige
Kemiska lärarförslagsnämnden, suppleant

2024-
Sjöbo demensförening, Sjöbo, Sverige
Interimordförande i styrelsen

Granskare av vetenskapliga manuskript inskickade för publicering i tidskrift

Annals of Anatomy, Current Alzheimer Research, GLIA, Neuroscience, Molecular Neurodegeneration, Biomarkers in Medicine, Molecular Autism, Acta Neuropathologica, Neuroscience & Biobehavioral Reviews, Neurobiology of disease, Neurology, PloS One, Journal of Neurology, Neurobiology of Aging, Journal of Alzheimer’s disease, Annals of Neurology, Aging Cell, Acta Neuropathologica Communications, Journal of Neuroscience, Scientific Reports, Translational Neurodegeneration, Science Advances, Acta Neurologica Belgica, Journal of Molecular Neuroscience

Redaktör för vetenskapliga tidskrifter
2012-2022
Associate editor, Journal of Alzheimer’s disease

2012-
Senior editor, Molecular Neurodegeneration

2018-2020
Academic editor, Plos One

2021-
Editorial board member, Aging Brain

Granskare av internationella forskningsanslagsansökningar

2013, 2019
AFI (ALZHEIMER FORSCHUNG INITIATIVE), Tyskland

2014, 2023
ZonMw - The Netherlands Organisation for Health Research and Development, Nederländerna       

2014, 2018
Alzheimer's Research UK, Storbritannien

2015
Alzheimer’s Society, Storbritannien

2016-2025
Alzheimer’s Association, USA       

2023
Israel Science Foundation

2025
Swiss National Science Foundation, Switzerland                                                                                  

ORGANISATION AV VETENSKAPLIGA INTERNATIONELLA KONFERENSER

2013
3rd International Conference on Molecular Neurodegeneration, Cannes, France

2016
4th International Conference on Molecular Neurodegeneration, Seoul, Korea

2018
5th International Conference on Molecular Neurodegeneration, Stockholm, Sweden

2020
6th International Conference on Molecular Neurodegeneration, Bangkok, Thailand
https://www.worldeventsforum.com/mn/ 

2022
ISMND 2022, Athens Greece

2024
ISMND 2024, Seoul, South Korea

2024-2026
ADPD Executive Organizer

2026
ISMND 2026, Hong Kong, China

VETENSKAPLIGA PUBLIKATIONER

Originalartiklar

1. Almeida FC, Patra K, Giannisis A, Niesnerova A, Nandakumar R, Ellis E, Oliveira TG, Nielsen HM. APOE genotype dictates lipidomic signatures in primary human hepatocytes. Journal of Lipid Research. 2024 Jan 11;65(2):100498. doi: 10.1016/j.jlr.2024.100498.
2. Giannisis A, Al-Grety A, Carlsson H, Howell JC, Hu WT, Kultima K, Nielsen HM. Plasma apolipoprotein E levels, isoform composition, and dimer profile in relation to plasma lipids in racially diverse patients with Alzheimer's disease and mild cognitive impairment. Alzheimers Research & Therapy. 2023 Jul 3;15(1):119. doi: 10.1186/s13195-023-01262-1
3. Kessler K, Giannisis A, Bial G, Foquet L, Nielsen HM*, Raber J*. Behavioral and cognitive performance of humanized APOEε3/ε3 liver mice in relation to plasma apolipoprotein E levels.
   Scientific Reports. 2023 Jan 31;13(1):1728
4. Giannisis A, Al-Grety A, Carlsson H, Patra K, Twohig D, Sando SB, Lauridsen C, Berge G, Grøntvedt GR, Bråthen G, White LR, Kultima K, Nielsen HM. Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer's disease. Alzheimers Research & Therapy. 2022 Aug 24;14(1):115
5. Giannisis A, Patra K, Edlund AK, Agirrezabala Nieto L, Benedicto-Gras J, Moussaud S, Dela Rosa A, Twohig D, Bengtsson T, Fu Y, Bu G, Bial G, Foquet L, Hammarstedt C, Strom S, Kannisto K, Raber J, Ellis E, Nielsen HM. Brain integrity is altered by hepatic APOEε4 in humanized-liver mice. Molecular Psychiatry. 2022 Aug;27(8):3533-3543
6. Edlund AK, Chen K, Lee W, Protas H, Su Y, Reiman E, Caselli R, Nielsen HM. Plasma Apolipoprotein E3 and Glucose Levels Are Associated in APOE ɛ3/ɛ4 Carriers. Journal of Alzheimer’s Disease. 2021;81(1):339-354
7. Patra K, Giannisis A, Edlund AK, Sando SB, Lauridsen C, Berge G, Grøntvedt GR, Bråthen G, White LR, NielsenHM. Plasma Apolipoprotein E Monomer and Dimer Profile and Relevance to Alzheimer's Disease. 2019. Journal of Alzheimer's disease Sep 3. doi: 10.3233/JAD-190175.
8. Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, Nordberg A, White LR, Nielsen HM. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease. 2018. Acta Neuropathologica Communications Nov 26;6(1):130.
9. Patra K, Soosaipillai A, Sando SB, Lauridsen C, Berge G, Møller I, Grøntvedt GR, Bråthen G, Begcevic I, Moussaud S, Minthon L, Hansson O, Diamandis EP, White LR, Nielsen HMN. Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease. 2018. Alzheimer’s Research & Therapy. Jan 29;10(1):9
10. Schultz N, Brännström K, Byman E, Moussaud S, Nielsen HMN, the Netherlands Brain Bank, Olofsson A, Wennström M. Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro. 2018. Aging Cell. Jun;17(3):e12728
11. Ogaki K, Martens YA, Heckman MG, Koga S, Walton RL, Soto-Ortolaza AI, Vargas E, Nielsen HMN, Fujioka S, Uitti RJ, Kanekiyo T, Wszolek ZK, Low PA, Singer W, Dickson DW, Bu G, Ross OA. Multiple system atrophy and apolipoprotein E. 2018. Movement Disorders Apr;33(4):647-650
12. Nielsen HM, Chen K, Lee W, Chen Y, Bauer RJ, 3rd, Reiman E, et al. Peripheral apoE isoform levels in cognitively normal APOE epsilon3/epsilon4 individuals are associated with regional gray matter volume and cerebral glucose metabolism. 2017. Alzheimer's Research & Therapy. Jan 30;9(1):5
13. Fu Y, Zhao J, Atagi Y, Nielsen HM, Liu CC, Zheng H, Shinohara M, Kanekiyo T, Bu G. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan. 2016. Molecular Neurodegeneration. May 5;11(1):37.
14. Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Hansson O, Nielsen HM. The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer's but Not Parkinson's Disease or Dementia with Lewy Bodies. 2015. PLoS One. Aug 13;10(8):e0135458.
15. Hoozemans JJM, van Haastert ES, Mulder SD, Nielsen HM, Veerhuis R, Ruijtenbeek R, Rozemuller AJM, Hilhorts R, van der Vies SM. Increased IRAK-4 kinase activity in Alzheimer’s disease:  IRAK-1/4 inhibitor I prevents pro-inflammatory cytokine secretion but not uptake of amyloid beta by primary human glia. 2014. Journal of Clinical & Cellular Immunology. August 4: 5:4
16. Schultz N, Nielsen HM, Minthon L, Malin Wennström. Involvement of MMP-9 in Amyloid-beta 1-42 induced shedding of pericytic NG2. 2014. Journal of Neuropathology and Experimental Neurology.  Jul;73(7):684-92
17. Zhao J, Fu Y, Liu-C-C, Shinohara M, Nielsen HM, Dong Q, Kanekiyo T, Bu G. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the RXR/RAR pathway. 2014. Journal of Biological Chemistry. Apr 18;289(16):11282-92
18. Wennström M, Nielsen  HM,  Orhan F, Londos E, Minthon L, Erhardt S. Kynurenic acid levels in cerebrospinal fluid from patients with Alzheimer´s disease or dementia with Lewy bodies. 2014. International Journal of Tryptophan Research. 7: 1–7
19. Martinez-Morillo E, Hansson O, Atagi Y, Bu G, Minthon L, Diamandis EP, Nielsen HM. Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer’s disease patients and controls. 2014. ACTA Neuropathologica. May;127(5):633-43
20. Martinez-Morillo E, Nielsen HM, Batruch I, Dabrovich AP, Begcevic I, Lopez MF, Minthon L, Bu G, Mattson N, Portelius E, Hansson O, Diamandis EP. Assessment of Peptide Chemical Modifications on the Development of an Accurate and Precise Multiplex Selected Reaction Monitoring Assay for Apolipoprotein E Isoforms. 2014. Journal of Proteome Research. Feb 7;13(2):1077
21. Mulder SD, Nielsen HM, Blankeinstein MA, Eikelenboom P, Veerhuis R. Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro. 2014. GLIA Apr;62(4):493-503
22. Nielsen HM, Hall S, Surova Y, Nägga K, Nilsson C, Minthon L, Hansson O, Wennström M. Low levels of soluble NG2 in cerebrospinal fluid from patients with dementia with Lewy bodies. 2014. Journal of Alzheimer’s disease. Jan 1;40(2):343-50
23. Lindqvist D, Hall S, Surova S, Sporre O, Nielsen H, Janelidze S, Brundin L, Hansson O. Cerebrospinal fluid inflammatory markers in Parkinson´s disease - associations with depression, fatigue, and cognitive impairment. 2013. Brain, behavior, and immunity. Oct;33:183-9
24. Nielsen HM, Ek D, Avdic U, Orbjörn C, Hansson O,The Netherlands Brain Bank, Veerhuis R,
    Rozemuller AJM, Brun A, Minthon L, Wennström M. NG2 cells, a new trail for Alzheimer’s disease mechanisms? 2013. Acta Neuropathologica Communications May 9;1(1):7
25. Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Boström F, Hansson O, Nielsen HM. Low levels of neurosin and its substrate α-synuclein in patients with synucleinopathy. 2013. PLoS One. 2013;8(1):e53250. Epub 2013 Jan 8
26. Westin K, Buchave P, Nielsen HM, Minthon L, Janciauskiene S, Hansson O. High levels of CCL2 are associated with faster cognitive decline in prodromal Alzheimer’s disease. 2012. PLoS One. 2012;7(1):e30525. Epub 2012 Jan 30
27. Wennström M, Londos E, Minthon L, Nielsen HM. Altered CSF orexin and α-synuclein levels in dementia patients. 2012. Journal of Alzheimer’s Disease Jan 1;29(1):125-32.
28. Nielsen HM, Palmqvist S, Minthon L, Londos E, Wennström M. Gender-dependent levels of hyaluronic acid in cerebrospinal fluid of patients with neurodegenerative dementia. 2012. Current Alzheimer Research. Mar 1;9(3):257-66
29. Mulder SD, Veerhuis R, Blankenstein MA, Nielsen HM. The effect of amyloid associated proteins on the expression of genes involved in amyloid clearance by adult human astrocytes. 2012. Experimental Neurology Jan;233(1):373-9. Epub 2011 Nov 10
30. Nielsen HM, Mulder SD, Beliën JAM, Musters RJP, Eikelenboom P, Veerhuis R. Astrocytic Aβ1-42 uptake is determined by Aβ-aggregation state and the presence of amyloid-associated proteins. 2010. Glia. 58(10):1235-46.
31. Nielsen HM, Veerhuis R, Holmqvist B, Janciauskiene S. Binding and uptake of Abeta1-42 by primary human astrocytes in vitro. 2009. Glia 57(9):978-88
32. Trouw LA, Nielsen HM, Minthon L, Londos E, Landberg G, Veerhuis R, Janciauskiene S, Blom AM. C4b-binding protein in Alzheimer's disease: binding to Abeta1-42 and to dead cells. 2008. Molecular Immunology 45(13):3649-60
33. Nielsen HM, Minthon L, Londos E, Blennow K, Miranda E, Perez J, Crowther DC, Lomas DA, Janciauskiene SM. Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies. 2007. Neurology 69(16):1569-1579
34. Nielsen HM, Londos E, Minthon L, Janciauskiene SM. Soluble adhesion molecules and angiotensin-converting enzyme in dementia. 2007. Neurobiology of Disease 26(1):27-35
35. Baker C, Nielsen HM, Minthon L, Wright HT, Chappell S, Okyere J, May S, Morgan K, Kalsheker N, Janciauskiene SM. 2007. Effects of Alzheimer's peptide and alpha1-antichymotrypsin on astrocyte gene expression. Neurobiology of Aging 28(1):51-61

Översiktsartiklar

1. Loch RA, Wang H, Perálvarez-Marín A, Berger P, Nielsen H, Chroni A, Luo J. Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases. Computational and Structural Biotechnology Journal. 2023 Jan 20;21:1189-1204
2. Fernández-Calle R., Konings SC., Frontiñán-Rubio J., García-Revilla J., Camprubí-Ferrer L., Svensson M., Martinson I., Boza-Serrano I., Venero JL., Nielsen HM., Gouras GK., Deierborg T. APOE in the bullseye of neurodegenerative diseases: Impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases. Molecular Neurodegeneration. 2022 Sep 24;17(1):62.
3. Twohig D, NielsenHM. α-synuclein in the pathophysiology of Alzheimer's disease. 2019. Molecular Neurodegeneration Jun 11;14(1):23
4. Wennström M, NielsenHM. Cell adhesion molecules in Alzheimer’s disease. 2012. Degenerative Neurological and Neuromuscular Disease. July 4;2012(2):65-77
5. Veerhuis R, Nielsen HM, Tenner AJ. Complement in the brain. 2011. Molecular Immunology 48(14):1592-603

Bokkapitel

1. Raber J, Nielsen HM. Humanized Liver Mouse and Human In Vitro Models to Study the Role of Liver-Derived Apolipoprotein E in Brain Function. From Biochemistry and Biology to Translational Medicine. Springer Nature, in press
2. Rodriguez-Vieitez E, Nielsen HM. Associations Between APOE Variants, Tau and α-Synuclein. Chapter 15. Adv Exp Med Biol. 2019;1184:177-186. doi: 10.1007/978-981-32-9358-8_15
3. Carrasquillo MM, Bu G, Nielsen HM. 2012. Chapter 2: Apolipoprotein E. ‘Genetic Variants in Alzheimer's Disease’ edited by Carrasquillo and Morgan. Springer NY. June 30, 2013. ISBN 978-1-4614-7308-4