Martina Galikova


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Arbetar vid Zoologiska institutionen
Telefon 08-16 40 89
Besöksadress Svante Arrheniusväg 18 B
Rum D 423
Postadress Zoologiska institutionen: Funktionell zoomorfologi 106 91 Stockholm

Om mig

My main research interests include endocrine regulation of energy metabolism, reproductive physiology, and aging in the model organism Drosophila melanogaster. After finishing my undergraduate studies in biology at Comenius University in Bratislava (Slovakia), I obtained PhD in genetics, in the field of reproductive physiology and aging of Drosophila melanogaster, at the University of Veterinary Medicine in Vienna (Austria). Subsequently, I continued as a postdoc at the Max Planck Institute for Biophysical Chemistry in Göttingen (Germany). During my first postdoc, I investigated hormonal regulations of physiology and metabolism, using Drosophila as a model for human metabolic and neurological disorders. In February 2017, I joined as a postdoc the division of Functional Animal Morphology at the Zoology Department of Stockholm University, in order to pursue my research interests in the neuroendocrine regulations of animal physiology. Currently, I investigate the regulation of water balance and energy homeostasis by the interplay of insulin-like peptides, Adipokinetic hormone and a novel metabolic regulator encoded by gene Ion transport peptide (ITP).



Brooke-Jones M., Gáliková M., Dircksen H. Cyanobacterial Neurotoxin Beta-Methyl-Amino-l-Alanine Affects Dopaminergic Neurons in Optic Ganglia and Brain of Daphnia magna. 2018. Toxins 10(12):527. doi: 10.3390/toxins10120527.

Gáliková M.*, Dircksen H., Nässel D. The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis of Drosophila. 2018. Plos Genetics 14(8): e1007618. doi: 10.1371/journal.pgen.1007618. *corresponding author

Klepsatel P.*, Procházka M., Gáliková M*. 2018. Crowding of Drosophila larvae affects lifespan and other life-history traits via reduced availability of dietary yeast. Experimental Gerontology. 110:298-308. doi: 10.1016/j.exger.2018.06.016. *corresponding author

Gáliková M.* and Klepsatel P*. 2018. Obesity and aging in the Drosophila model. International Journal of Molecular Sciences. 19:1896; doi:10.3390/ijms19071896. *corresponding author

Gáliková M.*, Klepsatel P., Münch J., Kühnlein R.P. Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila. 2017. Scientific Reports. Apr 19;7:46516. doi: 10.1038/srep46516. *corresponding author

Gáliková M*., Klepsatel P., Xu Y., Kühnlein R.P. 2017. The obesity-related Adipokinetic hormone controls feeding and expression of neuropeptide regulators of Drosophila metabolism. European Journal of Lipid Science and Technology. 119 (3), doi: 10.1002/ejlt.201600138. *corresponding author

Garschall K., Dellago H., Gáliková M., Schosserer M., Flatt T., Grillari J. Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span. 2017. Aging and Mechanism of Disease. doi:10.1038/s41514-017-0005-z

Klepsatel P., Gáliková M., Xu Y., Kühnlein R.P. 2016. Thermal stress depletes energy reserves in Drosophila.  Scientific Reports. Sep 19;6:33667. doi: 10.1038/srep33667.

Gáliková M., Diesner M., Klepsatel P., Hehlert P., Xu Y., Bickmeyer I., Predel R., Kühnlein R.P. 2015. Energy homeostasis control in Drosophila adipokinetic hormone mutants. Genetics. 201:665-683

Klepsatel, P., Gáliková M., Huber C. D., Flatt T. 2014. Similarities and differences in altitudinal and latitudinal clines in morphological traits in Drosophila melanogasterEvolution. 68:1385-98

Klepsatel P.*, Gáliková M.*, De Maio N., Ricci S., Schlötterer C., Flatt, T. 2013. Reproductive and post-reproductive life history of wild-caught Drosophila melanogaster under laboratory conditions. Journal of Evolutionary Biology 26: 1508-1520.* authors contributed equally

Klepsatel P., Gáliková M., De Maio N., Huber C. D., Schlötterer C., Flatt T. 2013. Variation in thermal performance and reaction norms among populations of Drosophila melanogasterEvolution 67: 3573-87.

Gáliková M., Klepsatel P, Senti G, Flatt T. 2011. Steroid hormone regulation of C. elegans and Drosophila aging and life history. Experimental Gerontology 46:141-147

Gáliková M., Flatt T. 2010. Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeoutAging 2:387-390


I urval från Stockholms universitets publikationsdatabas
  • 2017. Martina Gáliková (et al.). Scientific Reports 7

    The human PAPLA1 phospholipase family is associated with hereditary spastic paraplegia (HSP), a neurodegenerative syndrome characterized by progressive spasticity and weakness of the lower limbs. Taking advantage of a new Drosophila PAPLA1 mutant, we describe here novel functions of this phospholipase family in fly development, reproduction, and energy metabolism. Loss of Drosophila PAPLA1 reduces egg hatchability, pre-adult viability, developmental speed, and impairs reproductive functions of both males and females. In addition, our work describes novel metabolic roles of PAPLA1, manifested as decreased food intake, lower energy expenditure, and reduced ATP levels of the mutants. Moreover, PAPLA1 has an important role in the glycogen metabolism, being required for expression of several regulators of carbohydrate metabolism and for glycogen storage. In contrast, global loss of PAPLA1 does not affect fat reserves in adult flies. Interestingly, several of the PAPLA1 phenotypes in fly are reminiscent of symptoms described in some HSP patients, suggesting evolutionary conserved functions of PAPLA1 family in the affected processes. Altogether, this work reveals novel physiological functions of PAPLA1, which are likely evolutionary conserved from flies to humans.

  • 2018. Peter Klepsatel, Emanuel Procházka, Martina Gáliková. Experimental Gerontology 110, 298-308

    Conditions experienced during development have often long-lasting effects persisting into adulthood. In Drosophila, it is well-documented that larval crowding influences fitness-related traits such as body size, starvation resistance and lifespan. However, the underlying mechanism of this phenomenon is not well understood. Here, we show that the effects of increased larval density on life-history traits can be explained by decreased yeast availability in the diet during development. Yeast-poor larval diet alters various life-history traits and mimics the effects of larval crowding. In particular, reduced amount of yeast in larval diet prolongs developmental time, reduces body size, increases body fat content and starvation resistance, and prolongs Drosophila lifespan. Conversely, the effects of larval crowding can be rescued by increasing the concentration of the dietary yeast in the diet during development. Altogether, our results show that the well-known effects of larval crowding on life-history traits are mainly caused by the reduced availability of dietary yeasts due to increased larval competition.

  • 2018. Martina Gáliková, Peter Klepsatel. International Journal of Molecular Sciences 19 (7)

    Being overweight increases the risk of many metabolic disorders, but how it affects lifespan is not completely clear. Not all obese people become ill, and the exact mechanism that turns excessive fat storage into a health-threatening state remains unknown. Drosophila melanogaster has served as an excellent model for many diseases, including obesity, diabetes, and hyperglycemia-associated disorders, such as cardiomyopathy or nephropathy. Here, we review the connections between fat storage and aging in different types of fly obesity. Whereas obesity induced by high-fat or high-sugar diet is associated with hyperglycemia, cardiomyopathy, and in some cases, shortening of lifespan, there are also examples in which obesity correlates with longevity. Transgenic lines with downregulations of the insulin/insulin-like growth factor (IIS) and target of rapamycin (TOR) signaling pathways, flies reared under dietary restriction, and even certain longevity selection lines are obese, yet long-lived. The mechanisms that underlie the differential lifespans in distinct types of obesity remain to be elucidated, but fat turnover, inflammatory pathways, and dysregulations of glucose metabolism may play key roles. Altogether, Drosophila is an excellent model to study the physiology of adiposity in both health and disease.

  • Artikel The thirsty fly
    2018. Martina Gáliková, Heinrich Dircksen, Dick R. Nässel. PLOS Genetics

    Animals need to continuously adjust their water metabolism to the internal and external conditions. Homeostasis of body fluids thus requires tight regulation of water intake and excretion, and a balance between ingestion of water and solid food. Here, we investigated how these processes are coordinated in Drosophila melanogaster. We identified the first thirst-promoting and anti-diuretic hormone of Drosophila, encoded by the gene Ion transport peptide (ITP). This endocrine regulator belongs to the CHH (crustacean hyperglycemic hormone) family of peptide hormones. Using genetic gain- and loss-of-function experiments, we show that ITP signaling acts analogous to the human vasopressin and renin-angiotensin systems; expression of ITP is elevated by dehydration of the fly, and the peptide increases thirst while repressing excretion, promoting thus conservation of water resources. ITP responds to both osmotic and desiccation stress, and dysregulation of ITP signaling compromises the fly’s ability to cope with these stressors. In addition to the regulation of thirst and excretion, ITP also suppresses food intake. Altogether, our work identifies ITP as an important endocrine regulator of thirst and excretion, which integrates water homeostasis with feeding of Drosophila.

  • 2018. Megan Brooke-Jones, Martina Gáliková, Heinrich Dircksen. Toxins 10 (12)

    The non-proteinogenic amino acid beta-methyl-amino-l-alanine (BMAA) is a neurotoxin produced by cyanobacteria. BMAA accumulation in the brain of animals via biomagnification along the food web can contribute to the development of neurodegenerative diseases such as Amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC), the latter being associated with a loss of dopaminergic neurons. Daphnia magna is an important microcrustacean zooplankton species that plays a key role in aquatic food webs, and BMAA-producing cyanobacteria often form part of their diet. Here, we tested the effects of BMAA on putative neurodegeneration of newly identified specific dopaminergic neurons in the optic ganglia/brain complex of D. magna using quantitative tyrosine-hydroxylase immunohistochemistry and fluorescence cytometry. The dopaminergic system was analysed in fed and starved isogenic D. magna adults incubated under different BMAA concentrations over 4 days. Increased BMAA concentration showed significant decrease in the stainability of dopaminergic neurons of D. magna, with fed animals showing a more extreme loss. Furthermore, higher BMAA concentrations tended to increase offspring mortality during incubation. These results are indicative of ingested BMAA causing neurodegeneration of dopaminergic neurons in D. magna and adversely affecting reproduction. This may imply similar effects of BMAA on known human neurodegenerative diseases involving dopaminergic neurons.

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Senast uppdaterad: 11 december 2018

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