Marie-Louise Tjörnhammar

Marie-Louise Tjörnhammar

1:e forskningsingenjör

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Arbetar vid Institutionen för biokemi och biofysik
Telefon 08-16 42 68
Besöksadress Svante Arrhenius väg 16
Rum M 410
Postadress Institutionen för biokemi och biofysik 106 91 Stockholm


I urval från Stockholms universitets publikationsdatabas
  • 2008. Peter Järver (et al.).

    Transposable elements have emerged as a promising candidate for human non-viral gene-therapy. The Tc1/mariner transposon Sleeping Beauty is to date one of the most efficient transposons in mammals. Sleeping Beauty transposase has so far mostly been delivered to cells via a DNA source. This might cause spontaneous integration of the transposase gene and cause fatal damage to the affected cell. Hence, it would be advantageous to employ a non-genetic source for the transposase. We here show that a novel Cell-penetrating peptide, M918, has the ability to facilitate cellular delivery of both the transposase Sleeping Beauty as a protein and a transposon donor-plasmid carrying an antibiotic resistance gene in vitro. The technique is a simple and straightforward one-step method that might render a safe and efficient delivery platform for Sleeping Beauty mediated gene therapy.

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Senast uppdaterad: 2 oktober 2018

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