Pål Stenmark Professor i Biokemi
Kontakt
Namn och titel: Pål StenmarkProfessor i Biokemi
ORCID0000-0003-4777-3417 Länk till annan webbplats.
Arbetsplats: Institutionen för biokemi och biofysik Länk till annan webbplats.
Besöksadress Rum A 467Svante Arrhenius väg 16
Postadress Institutionen för biokemi och biofysik106 91 Stockholm
Forskargrupp
Structural and biophysical studies of Botulinum neurotoxins and novel Cancer targets in nucleotide metabolism
- The botulinum neurotoxins
The botulinum neurotoxins are the most toxic substances known; they are one million times more toxic than the cobra toxin. In spite of their extreme toxicity there has been a rapid expansion of the medical applications for the botulinum neurotoxins, with new applications constantly being discovered. This line of treatment is becoming the standard procedure for many conditions. The toxins are possible agents for bioterrorism and the development of countermeasures and vaccines are of high priority. We are studying the toxins using a wide variety of methods, including X-ray crystallography, to understand toxins basic mechanism and to improve their therapeutic properties.
- Structure based drug design
We also study enzymes involved in the nucleotide metabolism and DNA repair. We use X-ray crystallography to study the binding of these proteins to natural substrates and potent inhibitors that we are developing in an interdisciplinary research collaboration. We use structural based drug design to refine these inhibitors into novel cancer drugs.
Funding Sources
Our research is supported by grants from the Swedish Research Council, Swedish Cancer Society, KAW, The Swedish Brain Foundation, Novo Nordisk and the Åhlen foundation.