Lena Mäler Dean

Biophysical studies of protein - membrane interactions.

We have for many years focused our research on biophysical investigations of membrane protein – lipid interactions, and we have studied different aspects of these interactions; protein structure and, lipid dynamics and their dependence on interactions with membrane proteins. We use nuclear magnetic resonance (NMR) techniques, which are uniquely suited for this research, as they provide excellent tools for determining structure, and at the same time methods that can be used to investigate dynamics on a wide time-scale.

Group members 

Pontus Pettersson, Postdoc

Joan Patrick, PhD Student
 

Selected Publications

• Mäler, L. and Kowalewski, J. (2006)
  Nuclear Spin Relaxation in Liquids. Theory, Experiments and Applications.
  (Book, 426 pages), Taylor & Francis group, New York, London.
• Unnerståle, S., Lind, J., Papadopoulos, E. and Mäler, L. (2009)
  Solution structure of the HsapBK K+-channel voltage-sensor paddle sequence.
  Biochemistry, 48, 5813–5821.

Funding Sources

The Swedish Research Council, The Carl Trygger Foundation, The Magnus Bergvall Foundation