Research group Group Riedel

Aging is a strong determinant of human health and longevity. We study the molecular mechanisms that regulate aging, aiming to eventually target them for therapeutic purposes.
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C. elegans expressing a GFP-tagged version of the aging-preventive transcription factor DAF-16/FOXO. Copyright: Christian Riedel.

Our health and longevity is largely determined by the rate at which we age. Fortunately, aging is a plastic process. In our research group we use the nematode Caenorhabditis elegans as a model system to understand the pathways that can accelerate or slow aging. C. elegans is ideal for aging-related research, as it is technically well established, short-lived (allowing for lifespan as an easily measurable phenotype), and very responsive to alterations in its aging-regulatory pathways. These studies are complemented by efforts in human tissue culture, to verify human conservation and further explore our findings for therapeutic purposes. Finally, we are developing and applying screening approaches to identify aging-preventive compounds that have a high probability of working in humans.

Our research combines biochemistry (Proteomics, ChIP-Seq, mRNA-Seq, ATAC-Seq,…) with high-throughput bioinformatic, genetic, and pharmacological screening approaches, to understand the regulation of aging at molecular and mechanistic resolution and to identify aging-preventive interventions.

We thank our current funding sources: Vetenskapsrådet, Cancerfonden, Novo Nordisk Fonden, the National Institutes of Health, and Impetus Grants.

Members

Andrea Hinas

Senior Lab Manager

Department of Molecular Biosciences

Andrea Mosqueda Solis

Postdoc

Department of Medicine, Karolinska Institutet

Jérôme Salignon

Resarcher

Department of Medicine, Karolinska Institutet

Patryk Marcinkowski

PhD student

Department of Medicine, Karolinska Institutet

There are no research project connections.

LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling. Kavšek A, Salignon J, Millan-Ariño L, Marcinkowski P, Sen I, Riedel CG.Nat Commun. 2025 Jul 16;16(1):6566. doi: 10.1038/s41467-025-61786-y.PMID: 40670351

A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation. Breusegem SY, Houghton J, Romero-Bueno R, Fragoso-Luna A, Kentistou KA, Ong KK, Janssen AFJ, Bright NA, Riedel CG, Perry JRB, Askjaer P, Larrieu D.Nat Commun. 2025 Feb 16;16(1):1681. doi: 10.1038/s41467-025-56916-5.PMID: 39956852

Identification of DAF-16/FOXO Binding Partners in Caenorhabditis elegans by Immunoprecipitation and Mass Spectrometry.Marcinkowski P, Riedel CG.Methods Mol Biol. 2025;2871:19-31. doi: 10.1007/978-1-0716-4217-7_3.PMID: 39565575

A human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans. Romero-Bueno R, Fragoso-Luna A, Ayuso C, Mellmann N, Kavsek A, Riedel CG, Ward JD, Askjaer P.EMBO J. 2024 Nov;43(22):5718-5746. doi: 10.1038/s44318-024-00261-8. Epub 2024 Oct 4.PMID: 39367234

Cactus: a user-friendly and reproducible ATAC-Seq and mRNA-Seq analysis pipeline for data... - Salignon, J.*, Millan-Ariño, L., Garcia, M., Riedel, C.G.* (2024) Genomics 116(4):110858. (*: equal correspondence)

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene... - Emerson, F.J., Chiu, C., Lin, L.Y., Riedel, C.G., Zhu, M., Lee, S.S. (2024) Nature Communications 14;15(1):2320.

SIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans - Caron, M., Robert, V., Gely, L., Adrait, A., Pakulska, V., Couté, Y., Chevalier, M., Riedel, C.G., Bedet, C., Palladino, F. (2023) Development 150:dev201755.

Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis - Salignon, J., Faridani, O., Miliotis, T., Janssens, G.E., Chen, P., Zarrouki, B., Sandberg, R., Davidsson, P., Riedel, C.G. (2023) Aging 15.

Beyond Chronological Age: A Multidimensional Approach to Survival Prediction in Older Adults - Salignon, J., Rizzuto, D., Calderón-Larrañaga, A., Zucchelli, A., Fratiglioni, L., Riedel, C.G.*, Vetrano, D.L.* (2023) The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences 78(1):158-166. (*: equal correspondence)

Chromatin Immunoprecipitation and Sequencing (ChIP‐seq) Optimized for Application in Caenorhabdi... - Sen, I., Kavšek, A., Riedel, C.G. (2021) Current Protocols 1(7): e187.

DAF-16/FOXO requires Protein Phosphatase 4 to initiate the transcription of stress resistance and... - Sen, I., Chernobrovkin, A., Puerta Cavanzo, N., Liu, M., Lin, X.X., Baskaner, B., Brandenburg, S., Zubarev, R.A., Riedel, C.G. (2020) Nature Communications 11(1): 138.

Transcriptomics-based screening identifies pharmacological inhibition of Hsp90 as a means to defer.. - Janssens, G.E., Lin, X.X., Millan-Arino, L., Sen, I., Kavsek, A., Seinstra, R.I., Stroustrup, N., Nollen, E.A.A., Riedel, C.G. (2019) Cell Reports 27(2): 467-480.

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress... - Lin, X.X., Sen, I., Janssens, G.E., Zhou, X., Fonslow, B.R., Edgar, D., Stroustrup, N., Swoboda, P., Yates 3rd, J.R., Ruvkun, G., Riedel, C.G. (2018) Nature Communications 9(1): 4400.

The deubiquitylase MATH-33 controls DAF-16 stability and function in metabolism and longevity - Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C., Lillemeier, B.F., Kemphues, K., Yates, J.R. 3rd, O'Shea, C., Hunter, T., Dillin, A. (2015) Cell Metabolism 22(1):151-63.

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity - Riedel, C.G., Dowen, R.H., Lourenco, G.F., Kirienko, N.V., Heimbucher, T., West, J.A., Bowman, S.K., Kingston, R.E., Dillin, A., Asara, J.M., Ruvkun, G. (2013) Nature Cell Biology 15(5): 491-501.

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants - Curran, S.P., Wu, X., Riedel, C.G., Ruvkun, G. (2009) Nature 459: 1079-1084.

The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic... - Gregan, J.*, Riedel, C.G.*, Pidoux, A.L.*, Katou, Y., Rumpf, C., Schleiffer, A., Kearsey, S.E., Shirahige, K., Allshire, R.C., Nasmyth, K. (2007) Current Biology 17: 1190-1200. (*: equal contrib.)

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. - Riedel, C.G.*, Katis, V.L.*, Katou, Y., Mori, S., Itoh, T., Helmhart, W., Galova, M., Petronczki, M., Gregan, J., Cetin, B., Mudrak, I., Ogris, E., Mechtler, K., Pelletier, L., Buchholz, F., Shirahige, K., Nasmyth, K. (2006) Nature 441: 53-61. (*: equal contrib.)

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