Profiles

Pia Ädelroth

Pia Ädelroth

Professor

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Works at Department of Biochemistry and Biophysics
Telephone 08-16 41 83
Email pia.adelroth@dbb.su.se
Visiting address Svante Arrhenius väg 16
Room A 461
Postal address Institutionen för biokemi och biofysik 106 91 Stockholm

Research

Bacterial respiratory enzymes and nitric oxide metabolism

In most respiration chains, reduction of a terminal electron acceptor is linked to the production of a trans-membrane proton gradient, essential for the survival of the organism. The bacterial nitric oxide reductases (NOR) are part of an anaerobic respiration pathway termed denitrification, where they reduce the toxic nitric oxide (NO) to nitrous oxide (N2O). NORs belong to the same enzyme super-family as the oxygen-reducing proton pumping heme-copper oxidases (HCuOs) such as cytochrome c oxidase in human mitochondria. Our research aims at elucidating the structure-function relationship, cross-reactivity, energy conservation, proton transfer mechanisms and evolution of the NO (and O2)-reducing heme-copper oxidases.

We are also involved in a collaboration project on the 'Architecture and functional dynamics of the cellular power plant' funded by the Knut and Alice Wallenberg foundation, see:

http://www.dbb.su.se/research/research-projects/kaw-project-cellular-power-plant

 

Research groups

Young Ahn, Visiting Scientist

Shu Zhou, Postdoc

Ingrid Albertsson, PhD Student

Davinia Espejo, PhD Student

Olga Fedotovskaya, PhD Student

Nathalie Gonska, PhD Student

Maximilian Kahle, PhD Student

 

Selected Publications

  • Arjona, D., Wikström, M. and Ädelroth, P. (2015) ‘NO is a potent inhibitor of cbb3-type heme-copper oxidases’, FEBS Lett. 589, 1214–1218.
     
  • Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S. Arjona, D., Rousseau, D. L., Tajkhorshid, E., Ädelroth, P. and Gennis, R. B. (2014) ‘Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type oxygen reductase’, Proc. Natl. Acad. Sci. USA, 111, E4419-E4428.
     
  • ter Beek, J., Krause, N., Reimann, J., Lachmann, P., and Ädelroth, P. (2013) ‘The Nitric-Oxide reductase from Paracoccus denitrificans uses a single proton pathway’, J. Biol. Chem., 288, 30626-30635.
  • Lee, H. J., Reimann, J., Huang, Y., and Ädelroth, P. (2012) ‘Functional proton transfer pathways in the heme-copper oxidase superfamily’, Biochim. Biophys. Acta, 1817, 537-544.
     
  • Lee, H. J., Gennis, R. B., Ädelroth, P. (2011) ‘The entrance to the proton pathway in the cbb3-type oxidases’, Proc. Natl. Acad. Sci. USA, 108, 17661–17666.
 

 

Funding Sources

Our studies are supported by grants from the Swedish Research Council (VR) and the Faculty of sciences at Stockholm University.

Last updated: September 6, 2017

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