Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion
The pyruvate dehydrogenase complex is a multienzyme complex of megadalton size that converts pyruvate into acetyl-coenzyme A, thereby linking glycolysis to the citric acid cycle and to the biosynthesis of fatty acids. In a new study from DBB, scientists for the first time, reveal how the lipoyl domains interact with the core of a pyruvate dehydrogenase complex, to insert substrate into the active site. The study is published in Nature Communications.
Last updated:
September 8, 2021
Page editor:
Alexander Tuuling
Source: DBB
