Stockholm university

Andreas BarthProfessor of Biophysics



Bioanalytical infrared spectroscopy

Our group works at the intersection between basic and applied biophysics using experimental and computational methods. We study the structure and function of peptides and proteins, and the metabolism of biological cells. The time-resolved infrared spectroscopic techniques that we apply are very sensitive, as they are able to reveal the fate of single atoms in a working protein. Current projects are:

  • peptide aggregation processes relevant for Alzheimer's disease
  • molecular mechanism of enzymes (ATPase, pyruvate kinase)
  • monitoring and identifying microplastics in marine environments
  • simulation of infrared spectra


Group members

Cesare Baronio, Researcher

Xinfeng Wei, Researcher

Adela Janistova, PhD student

Faraz Vosough, PhD Student




  • A. Barth (2016)
    Two sides of the same coin: How enzymes distort substrates and vice versa. An infrared spectroscopic view on pyruvate kinase and Ca2+-ATPase.
    Biomedical Spectroscopy and Imaging 5, 101-114
  • A. Barth (2008)
    Structural dynamics of the Ca2+-ATPase studied by time-resolved infrared spectroscopy.
    Spectroscopy 22, 63-82
  • A. Barth (2007)
    Infrared spectroscopy of proteins.
    Biochim. Biophys. Acta - Bioenergetics 1767, 1073-1101
  • A. Barth, C. Zscherp (2002)
    What vibrations tell us about proteins.
    Quart. Rev. Biophys. 35, 369-430
  • C. Zscherp, A. Barth (2001)
    Reaction-induced infrared difference spectroscopy for the study of protein reaction mechanisms.
    Biochemistry 40, 1875-1883
  • A. Barth, C. Zscherp (2000)
    Substrate binding and enzyme function investigated by infrared spectroscopy.
    FEBS Lett. 477, 151-156
  • A. Barth (2000)
    The infrared absorption of amino acid side chains.
    Prog. Biophys. Mol. Biol. 72, 141-173


Research projects