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Elzbieta GlaserProfessor emerita

Research

Intracellular protein transport: signal peptides, molecular chaperones, proteolysis - connection to Alzheimer's disease.

Most of the mitochondrial and chloroplast proteins are nuclear encoded and synthesized as precursor proteins containing an N-terminal targeting peptide. After import, the targeting peptides are specifically cleaved off by the organellar processing peptidases. The cleaved targeting peptides are toxic to the organellar membranes and are rapidly degraded by a novel organellar peptidasome Presequence Protease (PreP), identified in our laboratory. We are using a combination of biochemical, molecular biological, biophysical and bioinformatic approaches to investigate different aspects of intracellular protein transport, such as sorting mechanisms, dual protein targeting, interaction of signal peptides with molecular chaperones and degradation of signal peptides by the PreP peptidasome. Furthermore, we are investigating the role of human mitochondrial PreP in Alzheimer´s disease as hPreP degrades amyloid-beta peptide forming insoluble fibers associated with Alzheimer´s disease.
 

 

Selected Recent Publications

 

Funding Sources

The Swedish Research Council (VR-NT); Alzheimersfonden; Carl Tryggers Foundation; Fundação para a Ciência e a Tecnologia, Portugal