Profiles

Head

Hongyi Xu

Researcher

Visa sidan på svenska
Works at Department of Materials and Environmental Chemistry
Email hongyi.xu@mmk.su.se
Visiting address Svante Arrhenius väg 16 C
Room C 562
Postal address Institutionen för material- och miljökemi 106 91 Stockholm

About me

Bachelor of Engineering with Honours (Mechatronic), the University of Queensland, Australia

PhD in Engineering (Materials, Electron Microscopy), the University of Queensland, Australia

 

After completing a Bachelor of Engineering (Mechatronics) degree at the University of Queensland, Hongyi went on to pursue a PhD degree in materials engineering, specialized in electron microscopy and semiconductor nano-materials. The Australian Government sponsored his PhD study through the Australian Postgraduate Award program. He obtained his PhD degree at UQ in Dec 2013, and received the Dean’s accommodation for academic excellence as well as the best thesis of the year award from the School of Mechanical and Mining Engineering. In Feb. 2014, Hongyi started his postdoc fellowship (Wenner-Gren Foundation postdoc award) in Prof. Xiaodong Zou’s group at Stockholm University. In 2015, he initiated the development of MicroED (3D electron diffraction technique for studying biomolecules) at Zou’s group. Hongyi became a principle investigator in 2018 to further develop and apply electron crystallography methods for studying structures of biomolecules. Recently, Hongyi and colleagues solved the first new protein structure using MicroED. They also shown that it is possible to reveal protein inhibitor binding by MicroED. He is now working as a researcher/principle investigator (with 4 external research grants) at Stockholm University.

  

Teaching

KZ8010 Advanced TEM - Lecturer

 

Research

Knowing the 3D atomic structures of materials and biomolecules is crucial for understanding their functions. X-ray diffraction is currently the most important technique for determination of 3D atomic structures, but requires large crystals which are often difficult to obtain. Due to the strong interactions between electrons and matter, crystals that are considered as powder in X-ray crystallography can be treated as single crystals by 3D electron diffraction methods. This enables structure determination of materials and organic molecules from micron- to nanometer-sized 3D crystals that are too small for conventional X-ray diffraction.

Over the past decades, a number of 3D ED methods have been developed for structure determination. Thanks to the recent advancement in CMOS and hybrid detector technology, it is now feasible to collect diffraction data in movie mode while continuously rotating the crystal (continuous rotation election diffraction, cRED, also known as MicroED in structural biology). Benefiting from these technological advances, structure determination can now be accomplished within few hours. Recently, fully automated serial rotation electron diffraction data collection and processing have been realized by our group. By using 3D ED and MicroED methods, we have solved more than 180 novel crystal structures of small inorganic compounds (including zeolite, MOF, COF and minerals) and organic molecules (pharmaceuticals, small organic molecules, peptides and proteins) in the past 6 years. We aim to further develop new electron crystallography methods and more importantly spread them to labs around the world.

 

Publications

2020

Clabbers, M.T.B.* & Xu, H.* Acta Crystallographica Section D 2020 (accepted)

Clabbers, M.T.B.* & Xu, H.* Drug Discovery Today: Technology 2020 (accepted)

Xu, H.; Ångström, J.; Eklund, T.; Amann-Winkel, K. Journal of Physical Chemistry B 2020, 124, 9283-9288.

Roslova, M.; Smeets, S.; Wang, B.; Thersleff, T.; Xu, H.; Zou, X. Journal of Applied Crystrallograph 2020, 53, 1217-1224

Leubner, S.; Bengtsson, V.E.G.; Synnatschke, K.; Gosch, J.; Koch, A.; Reinsch, H.; Xu, H.; Backes, C.; Zou, X.; Stock, N. Journal of the American Chemical Society 2020, 142, 15995-16000.

Cichocka, M.O.; Liang, Z.; Feng, D.; Back, S.; Siahrostami, S.; Wang, X.; Samperisi, L.; Sun, Y.; Xu H.; Hedin, N.; Zheng, H.; Zou, X.; Zhou, H.-C.; Huang, Z. Journal of the American Chemical Society 2020, 142, 15386-15395.

Clabbers, M.T.B.; Fisher S.Z.; Coincon, M.; Zou, X.; Xu, H.* Communications Biology 2020, 3, 1-8.

Leubner, S.; Bengtsson, V.E.G; Inge, A.K.; Wahiduzzaman, M.; Stinke, F.; Jaworski, A.; Xu, H.; Halis, S.; Ronfeldt, P.; Reinsch, H.; Maurin, G.; Zou, X.; Stock, N. Dalton Transacations 2020, 49.

Broadhurst, E.; Xu, H.*; Clabbers, M.T.B.; Lightowler, M.; Nudelman, F.; Zou, X.*; Parsons, S.* IUCrJ 2020, 7.

 

2019

Grape, E.S.; Xu, H.; Cheung, O.; Calmels, M.; Zhao, J.; Dejoie, C.; Proserpio, D.M.; Zou, X.; Inge, A.K. Crystal Growth & Design 2019, 20, 320-329.

Xu, H.; Zou, X. Science 2019, 364, 632-633

Lenzen, D.; Zhao, J.; Ernst, S-J.; Wahiduzzaman, M.; Inge A.K.; Frohlich, D.; Xu, H.; Bart, H-J.; Janiak, C.; Henninger, S.; Maurin, G.; Zou, X.; Stock, N. Nature Communications 2019, 1, 1-9.

Xu, H.*; Lebrette, H.; Clabbers M.T.B.; Zhao, J.; Griese, J.J.; Zou, X.; Hogbom, M. Science advances 2019, 5, eaax4621.

Kapaca, E.; Burton, A.; Terefenko, E.; Vroman, H.; Weston, S.C.; Kochersperger, M.; Afeworki, M.; Paur, C.; Koziol, L.; Ravikovitch, P.; Xu, H.; Zou, X.; Willhammar, T. Inorganic Chemistry 2019, 58, 12854-12858.

 

 

2018

Xu, H.; Lebrette, H. (Equal Contribution); Yang, T.; Srinivas, V.; Hovmoller, S.; Hogbom, M.; Zou, X.D. Structure 2018, 26, 667-675.

Yuan, S.; Qin, J.S.; Xu, H.Q.; Su, J.; Rossi, D.; Chen, Y.P.; Zhang, L.L.; Lollar, C.; Wang, Q.; Jiang, H.L.; Son, D.H.; Xu, H.; Huang, Z.H.; Zou, X.D.; Zhou, H.C. ACS Central Science 2018, 4, 105-111.

Wang, L.; Xu, H.; Yan, N.N.; Correll, S.; Xu S.T.; Guo, P.; Tian, P.; Liu Z.M. CrystEngComm 2018, 20, 699-702.

Yan, N.N.; Xu, H.; Zhang, W.N.; Sun, T.T.; Guo, P.; Tian, P.; Liu, Z.M.  Microporous Mesoporous Mater. 2018, 264, 55-59.

Wang, Y.C.; Yan, T.M.; Xu, H.; Zou, X.D.; Wan, W.   J. Appl. Crystallogr. 2018, 51, 1094-1101.

Carmona, F. J.; Maldonado, C.R.; Ikemura, S.; Romao, C.C.; Huang, Z.H.; Xu, H.; Zou, X.D.; Kitagawa, S.; Furukawa, S.; Barea, E. ACS Appl. Mater. Interfaces 2018, 10, 31158-31167.

Wang, B.; Rhauderwiek, T.; Inge, A.K.; Xu, H.; Yang, T.M.; Huang, Z.H.; Stock, N.; Zou, X.D. Chemistry – A European Journal 2018, 24, 17429-17433.

 

2017

Wang, Y.; Takki, S.; Cheung, O.; Xu, H.; Wan, W; Ohrstrom, L.; Inge, A.K. Chemical Communications 2017, 53, 7018-7021.

 

2016

Inge, A.K.; Köppen, M.; Su, J.; Feyand, M.; Xu, H.; Zou, X.; O’Keeffe, M.; Stock, N. Journal of the American Chemical Society 2016, 138, 1970-1976.

Shin, J.; Xu, H. (equal contribution); Seo, S.; Guo, P.; Min, J.G.; Wright, P.; Zou, X.; Hong S.B. Angewandte Chemie International Edition 2016, In-Press (doi: 10.1002/anie.201510726).

 

2015

Xia, C.; Ju, L.; Zhao, Y.; Xu, H.; Zhu, B.; Gao, F.; Lin, M.; Dai, Z.; Zou, X.; Shu, X. Chinese Journal of Catalysis 2015, 36, 845-854.

 

2014

Zhang, Z.; Lu, Z.; Xu, H.; Chen, P.; Lu, W.; Zou J. Nano Research 2014, 7,1640-1649.

Yang, T.; Liu, J.; Zhou, R.; Chen, Z.; Xu, H.; Qiao, S.; Monteiro, M. Journal of Materials Chemistry A 2014, 2, 18139-18146.

Yun, Y.; Wan, W.; Rabbani, F.; Su, J.; Xu, H.; Hovmöller, S.; Johnsson, M.; Zou, X. Journal of Applied Crystallography 2014, 47, 2048-2054.

 

2013

Cheng, L. N.; Chen, Z. G.; Yang, L.; Han, G.; Xu, H. Y.; Snyder, G. J.; Lu, G. Q.; Zou, J. Journal of Physical Chemistry C 2013, 117, 12458-12464.

Guo, Y. N.; Xu, H. Y.; Auchterlonie, G. J.; Burgess, T.; Joyce, H. J.; Gao, Q.; Tan, H. H.; Jagadish, C.; Shu, H. B.; Chen, X. S.; Lu, W.; Kim, Y.; Zou, J. Nano Letters 2013, 13, 643-650.

Liao, Z. M.; Chen, Z. G.; Lu, Z. Y.; Xu, H. Y.; Guo, Y. N.; Sun, W.; Zhang, Z.; Yang, L.; Chen, P. P.; Lu, W.; Zou, J. Applied Physics Letters 2013, 102, 063106.

Niu, Y. T.; Yu, M. H.; Hartono, S. B.; Yang, J.; Xu, H. Y.; Zhang, H. W.; Zhang, J.; Zou, J.; Dexter, A.; Gu, W. Y.; Yu, C. Z. Advanced Materials 2013, 25, 6233-6237.

Qian, K.; Zhou, L.; Liu, J.; Yang, J.; Xu, H. Y.; Yu, M. H.; Nouwens, A.; Zou, J.; Monteiro, M. J.; Yu, C. Z. Scientific Reports 2013, 3, 1415.

Sun, W.; Guo, Y. N.; Xu, H. Y.; Gao, Q.; Tan, H. H.; Jagadish, C.; Zou, J. Applied Physics Letters 2013, 103, 4, 223104.

Sun, W.; Guo, Y. N.; Xu, H. Y.; Liao, Z. M.; Gao, Q.; Tan, H. H.; Jagadish, C.; Zou, J. Journal of Physical Chemistry C 2013, 117, 19234-19238.

Wang, S. L.; Chen, G. L.; Huang, H.; Ma, S. J.; Xu, H. Y.; He, Y. H.; Zou, J. Nanotechnology 2013, 24, 505705.

Xu, H. Y.; Guo, Y. N.; Liao, Z. M.; Sun, W.; Gao, Q.; Tan, H. H.; Jagadish, C.; Zou, J. Applied Physics Letters 2013, 102, 203108.

Yang, L.; Chen, Z. G.; Han, G.; Cheng, L. N.; Xu, H. Y.; Zou, J. Crystal Growth & Design 2013, 13, 4796-4802.

Zhang, Z.; Lu, Z. Y.; Chen, P. P.; Xu, H. Y.; Guo, Y. N.; Liao, Z. M.; Shi, S. X.; Lu, W.; Zou, J. Applied Physics Letters 2013, 103, 073109.

Zhou, L.; Xu, H. Y.; Zhang, H. W.; Yang, J.; Hartono, S. B.; Qian, K.; Zou, J.; Yu, C. Z. Chemical Communication 2013, 49, 8695-8697.

Zong, X.; Thaweesak, S.; Xu, H. Y.; Xing, Z.; Zou, J.; Lu, G. Q.; Wang, L. Z. Physical Chemistry Chemical Physics 2013, 15, 12314-12321.

 

2012

Cheng, L. N.; Chen, Z. G.; Ma, S.; Zhang, Z. D.; Wang, Y.; Xu, H. Y.; Yang, L.; Han, G.; Jack, K.; Lu, G. Q.; Zou, J. Journal of the American Chemical Society 2012, 134, 18920-18923.

Kang, J. H.; Gao, Q.; Parkinson, P.; Joyce, H. J.; Tan, H. H.; Kim, Y.; Guo, Y.; Xu, H.; Zou, J.; Jagadish, C. Nanotechnology 2012, 23, 415702.

Xia, H.; Lu, Z. Y.; Li, T. X.; Parkinson, P.; Liao, Z. M.; Liu, F. H.; Lu, W.; Hu, W. D.; Chen, P. P.; Xu, H. Y.; Zou, J.; Jagadish, C. Acs Nano 2012, 6, 6005-6013.

Xu, H. Y.; Guo, Y. N.; Sun, W.; Liao, Z. M.; Burgess, T.; Lu, H. F.; Gao, Q.; Tan, H. H.; Jagadish, C.; Zou, J. Nanoscale Research Letters 2012, 7, 589.

Xu, H. Y.; Wang, Y.; Guo, Y. N.; Liao, Z. M.; Gao, Q.; Jiang, N.; Tan, H. H.; Jagadish, C.; Zou, J. Crystal Growth & Design 2012, 12, 2018-2022.

Xu, H. Y.; Wang, Y.; Guo, Y. N.; Liao, Z. M.; Gao, Q.; Tan, H. H.; Jagadish, C.; Zou, J. Nano Letters 2012, 12, 5744-5749.

 

2011

Kang, J. H.; Gao, Q.; Joyce, H. J.; Tan, H. H.; Jagadish, C.; Kim, Y.; Guo, Y. A.; Xu, H. Y.; Zou, J.; Fickenscher, M. A.; Smith, L. M.; Jackson, H. E.; Yarrison-Rice, J. M. Crystal Growth & Design 2011, 11, 3109-3114.

Wang, Y.; Liao, Z. M.; Xu, H. Y.; Xiu, F. X.; Kou, X. F.; Wang, K. L.; Drennan, J.; Zou, J. Nanoscale Research Letters 2011, 6, 24.

Yuan, P.; Sun, J. L.; Xu, H. Y.; Zhou, L.; Liu, J. Z.; Zhang, D. L.; Wang, Y. H.; Jack, K. S.; Drennan, J.; Zhao, D. Y.; Lu, G. Q.; Zou, X. D.; Zou, J.; Yu, C. Z. Chemistry of Materials 2011, 23, 229-238.

Zhou, W.; Ge, L.; Chen, Z. G.; Liang, F. L.; Xu, H. Y.; Motuzas, J.; Julbe, A.; Zhu, Z. H. Chemistry of Materials 2011, 23, 4193-4198.

 

2010

Chen, Z. G.; Cheng, L. N.; Xu, H. Y.; Liu, J. Z.; Zou, J.; Sekiguchi, T.; Lu, G. Q.; Cheng, H. M. Advanced Materials 2010, 22, 2376-2380.

Fu, L. T.; Chen, Z. G.; Wang, D. W.; Cheng, L. N.; Xu, H. Y.; Liu, J. Z.; Cong, H. T.; Lu, G. Q.; Zou, J. Journal of Physical Chemistry C 2010, 114, 9627-9633.

Kang, J. H.; Gao, Q.; Joyce, H. J.; Tan, H. H.; Jagadish, C.; Kim, Y.; Choi, D. Y.; Guo, Y.; Xu, H.; Zou, J.; Fickenscher, M. A.; Smith, L. M.; Jackson, H. E.; Yarrison-Rice, J. M. Nanotechnology 2010, 21, 035604.

Liu, J. Z.; Chen, J. H.; Yang, X. B.; Ren, S.; Wu, C. L.; Xu, H. Y.; Zou, J. Scripta Materialia 2010, 63, 1061-1064.

Wang, Y.; Xiu, F. X.; Xu, H. Y.; Li, D.; Kou, X. F.; Wang, K. L.; Jacob, A. P.; Zou, J. Journal of Crystal Growth 2010, 312, 3034-3039.

 

2009

Xu, H. Y.; Guo, Y. N.; Wang, Y.; Zou, J.; Kang, J. H.; Gao, Q.; Tan, H. H.; Jagadish, C. Journal of Applied Physics 2009, 106, 083514.

 

Last updated: December 8, 2020

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