Research group Martin Högbom's research group

Our main area of interest and expertise is how protein structure relates to function, in particular in proteins that utilize redox active metal cofactors or radicals for catalysis.

A central theme of our research is to obtain structural information of high-valent protein-coordinated metal sites used for extremely challenging chemical reactions. This information is central for the design of novel bioimetic catalysts for green chemistry and energy conversion. We also study the unique respiratory systems in Mycobacteria to characterize their structure and function. Energy metabolism in these pathogens is currently emerging as a promising new drug target.

We use tools such as synchrotron and free-electron laser X-ray crystallography, Cryo-EM, protein design, enzymatic assays and a variety of spectroscopic techniques.

This research group has no members.

There are no research project connections.

Department of Biochemistry and Biophysics

Swedish Research Council Awards Seven Grants to DBB Researchers

The Swedish Research Council (Vetenskapsrådet) has awarded research grants to seven researchers at the Department of Biochemistry and Biophysics (DBB). Vetenskapsrådet funds awards for both newly established researchers, and for established researchers to undertake studies in a wide range of areas.

Revealing the secrets behind nature’s impossible chemistry

Some chemical reactions in nature are virtually impossible to replicate in research labs, particularly the way proteins control chemical reactions using metal ions and radicals. Martin Högbom is seeking to understand nature’s ability to perform seemingly impossible chemistry.

Department of Biochemistry and Biophysics

Revealing mechanism of potential anti-TB drug opens possibilities for further cure development

One of the greatest challenges of modern-day science is to address the rise of multidrug-resistant diseases and the need for new functional antibiotics. In a study published in PNAS (Proceedings of the National Academy of Sciences), researchers at Stockholm University describe the mode of action of a potential anti-tuberculosis (anti-TB) compound, lansoprazole sulphide.

Department of Biochemistry and Biophysics

Radical Tool in Nature's Chemistry Toolbox Depicted

Researchers at DBB have determined the structure of one of nature's sharpest chemical tools, a protein radical. The results help us understand how nature can carry out very challenging chemical reactions and can ultimately be used in both medicine and green chemistry applications.

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