The innate immune system is rapidly responding to defend against incoming pathogens. Our research is aiming to explore pathogen interaction with host cell signaling, and its correlation with subversion or induction of protective innate responses. The overall aim is to study early innate immune responses against virus infections to reveal early biomarkers and novel therapeutic targets. We are in particular interested in responses engaged after Toll-like-receptor signaling and after contact with apoptotic cells. The aim with these projects is to enhance the understanding of early innate mechanisms during infections or tissue damage with the dendritic cell in focus. This knowledge will contribute to novel approaches of immune modeling during immune pathogenesis and the development of vaccine adjuvants, where the activation of dendritic cells has emerged as a key event in shaping the following adaptive immune responses.
Key words: Dendritic cell, TLR, apoptotic cell, cytokines, host restriction factors, HIV-1, RSV, TBEV, influenza.
Selected publications
Poux C, Dondalska A, Bergenstråhle J, Pålsson S, Contreras V, Arasa C, Järver P, Albert J, Busse DC, LeGrand R, Lundeberg J, Tregoning JS, Spetz AL. A Single Stranded Oligonucleotide-Inhibits Toll-Like Receptor 3 Activation and Reduces Influenza A (H1N1) Infection. Front Immunol. 2019 Sep 12; 10:2161. doi: 10.3389/fimmu.2019.02161. eCollection 2019.
Ezzat, K, Pernemalm, M, Pålsson, S, Roberts, T.C, Järver,P, Dondalska,A, Bestas,B, Sobkowiak,M.J, Levänen,B, Sköld,M, Thompson,E.A, Saher,O, Kari,O.K, Lajunen,T, Sverremark Ekström,E, Nilsson,C, Ishchenko,Y, Malm,T, Wood,M.J.A, Power,U.F, Masich,S, Lindén,A, Sandberg,J.K, Lehtiö,J, Spetz,A.L*, Samir EL Andaloussi, S.EL.* The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation. Nat. Commun. 2019 10(1) 2331-. Ezzat, K and Spetz, AL corresponding authors. *Equal contribution.
Järver P, Dondalska A, Poux C, Sandberg A, Bergenstråhle J, Sköld AE, Dereuddre-Bosquet N, Martinon F, Pålsson S, Zaghloul E, Brodin D, Sander B, Lennox KA, Behlke MA, El-Andaloussi S, Lehtiö J, Lundeberg J, LeGrand R, Spetz AL. Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis. Sci Rep. 2018 Oct 26;8(1):15841. doi: 10.1038/s41598-018-33960-4.
Adam L, López-González M, Björk A, Pålsson S, Poux C, Wahren-Herlenius M, Fernández C, Spetz AL. Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp. Front Immunol. 2018 Sep 3;9:1939. doi: 10.3389/fimmu.2018.01939. eCollection 2018.
Uchtenhagen H, Schiffner T, Bowles E, Heyndrickx L, LaBranche C, Applequist SE, Jansson M, De Silva T, Back JW, Achour A, Scarlatti G, Fomsgaard A, Montefiori D, Stewart-Jones G, Spetz AL. Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein. J Immunol. 2014 Jun 15;192(12):5802-12.
Mohanram V, Sköld AE, Bächle SM, Pathak SK, Spetz AL. (2013) IFN-α induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells. J Immunol. 190(7):3346-53.
Sköld AE, Hasan M, Vargas L, Saidi H, Bosquet N, Le Grand R, Smith CI, Spetz AL. (2012) Single-stranded DNA oligonucleotides inhibit TLR3-mediated responses in human monocyte-derived dendritic cells and in vivo in cynomolgus macaques. Blood.120(4):768-77.
Pathak SK, Sköld AE, Mohanram V, Persson C, Johansson U, Spetz AL. (2012) Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins. J Biol Chem. 287(17):13731-42.
Mohanram V, Johansson U, Sköld AE, Fink J, Kumar Pathak S, Mäkitalo B, Walther-Jallow L, Spetz AL. (2011) Exposure to apoptotic activated CD4+ T cells induces maturation and APOBEC3G-mediated inhibition of HIV-1 infection in dendritic cells. PLoS One. 6(6):e21171.
Ozkaya Sahin G, Bowles EJ, Parker J, Uchtenhagen H, Sheik-Khalil E, Taylor S, Pybus OG, Mäkitalo B, Walther-Jallow L, Spångberg M, Thorstensson R, Achour A, Fenyö EM, Stewart-Jones GB, Spetz AL. (2010) Generation of neutralizing antibodies and divergence of SIVmac239 in cynomolgus macaques following short-term early antiretroviral therapy. PLoS Pathog. 6(9):e1001084.
See all publications
(Link to researcher ID)
