Uchtenhagen H, Schiffner T, Bowles E, Heyndrickx L, LaBranche C, Applequist SE, Jansson M, De Silva T, Back JW, Achour A, Scarlatti G, Fomsgaard A, Montefiori D, Stewart-Jones G, Spetz AL. Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein. J Immunol. 2014 Jun 15;192(12):5802-12.
Pathak, S.K., Tavares, R., de Klerk, N., Spetz, AL. and Jonsson, AB. Helicobacter pylori protein JHP0290 binds to multiple immune cells and induces macrophages apoptosis via tumor necrosis factor-α-dependent and independent pathways, PloS One, 2013 Nov 1;8(11):e77872
Mohanram,V., Sköld,A.E., Bächle, S.M., Pathak,S.K., Spetz, AL. IFN-a Induces Apolipoprotein B mRNA Editing Enzyme, Catalytic-like 3 (APOBEC3) G, F and A in Immature Dendritic Cells and Limits HIV-1 Spread to CD4+ T-cells. J Immunol. 2013 Apr 1;190(7):3346-53
Spetz AL, Chiodi F.Reduction of HIV-1 Load in Semen During Follow-up Study of RV144 Vaccine Trial Boosts Interest for Novel Correlates of Immune Protection in Genital Mucosa. J Infect Dis. 2013 Apr 15;207(8):1189-92.
Sköld AE, Hasan M, Vargas L, Saidi H, Bosquet N, Le Grand R, Smith CI, Spetz AL. Single-stranded DNA oligonucleotides inhibit TLR3-mediated responses in human monocyte-derived dendritic cells and in vivo in cynomolgus macaques. Blood. 2012 Jul 26;120(4):768-77.
Pathak SK, Sköld AE, Mohanram V, Persson C, Johansson U, Spetz AL. Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins. J Biol Chem. 2012 Apr 20;287(17):13731-42.
Koopman,G., Beenhakker,N., Hofman,S., Walther-Jallow,L., Mäkitalo,B., Mooij,P., Anderson,J., Verschoor,E., Bogers,W., Heeney,J.L., Spetz, AL. Immunization with Apoptotic Pseudovirus Transduced Cells Induces both Cellular and Humoral Responses: a Proof-of-Concept study in Macaques .Vaccine, 2012 Mar 28;30(15):2523-34
Mohanram, V, Johansson, U., Sköld,A.E., Fink,J.,Kumar Pathak, S., Mäkitalo,B., Walther-Jallow, L. and Spetz, AL. Exposure to Apoptotic Activated CD4+ T cells Induces Maturation and APOBEC3G Mediated Inhibition of HIV-1 Infection in Dendritic Cells. PLoS One. 2011;6(6):e21171. Epub 2011 Jun 16.
Uchtenhagen, H., Friemann, R.,Raszewski, G., Spetz, AL.,Nilsson, L. and Achour, A. Crystal Structure of the HIV-2 Neutralizing Fab Fragment 7C8 with High Specificity to the V3 Region of gp125. PloS One. 2011 Apr 26;6(4):e18767
Gómez Román,V.R., Vinner, L., Grevstad, B., Hansen, J.J., Wegmann, F., Spetz, AL. and Fomsgaard, A. Development of standard operating procedures to obtain longitudinal vaginal specimens from nulliparous rabbits as part of HIV vaccine mucosal immunogenicity studies. J. Immunol. Methods. 2010 Dec 15;363(1):29-41
Özkaya Şahin,G, Bowles,E.J.,Parker,P, Uchtenhagen,H, Sheik-Khalil, E., Taylor, S., Pybus,O., Mäkitalo, B.,Walther Jallow,L., Spångberg,M., Thorstensson,R., Achour,A., Fenyö,E.-M., Stewart-Jones,G., and Spetz AL. Generation of Neutralizing Antibodies and Divergence of SIVmac239 in Cynomolgus Macaques Following Short-term Early Antiretroviral Therapy. PLoS Pathogens. 2010 Sep 2;6(9):e1001084
Johansson U, Walther-Jallow L, Hofmann A, Spetz AL. Dendritic cells are able to produce IL-12p70 after uptake of apoptotic cells. Immunobiology. 2011 Jan-Feb;216(1-2):251-5
Kumawat K, Pathak SK, Spetz AL, Kundu M, Basu J. Exogenous Nef is an inhibitor of Mycobacterium tuberculosis-induced tumor necrosis factor-alpha production and macrophage apoptosis. J Biol Chem. 2010 Apr 23;285(17):12629-37.
Jespers,V., Harandi, A., Hinkula,J., Medaglini,D., Le Grand,R., Stahl-Hennig,C., Bogers, W., El Habib,R., Wegmann,F., Fraser,C., Cranage,M., Shattock,R. and Spetz, A.-L. Assessment of mucosal immunity to HIV-1. Expert Review of Vaccines. 2010 Apr;9(4):381-94.
Brave A, Johansson U, Hallengärd D, Heidari S, Gullberg H, Wahren B, Hinkula J, Spetz AL. Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes. Vaccine. 2010 Feb 25;28(9):2080-7
Uchtenhagen H, Sourial S, Friemann R, Ehnlund M, Spetz AL, Harris RA, Madhurantakam C, Achour A. Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8. Acta Crystallogr. 2009 Jul 1;65(Pt 7):705-8.
Hinkula J, Walther-Jallow L, Laurén A, Mäkitalo B, Oberg M, Wahren B, Fenyö EM, Spetz AL. Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells. Vaccine. 2009 Oct 30;27(46):6424-31.
Yu L, Mohanram V, Simonson OE, Smith CI, Spetz AL, Mohamed AJ. Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets. Biochem Biophys Res Commun. 2009 Jul 17;385(1):100-5. Epub 2009 May 6.
Smed-Sörensen, A., Moll, M., Cheng, T-Y., Loré, K., Norlin, A-C., Perbeck, L., Moody, B., Spetz, AL., Sandberg, J. IgG regulates the CD1 expression profile and lipid antigen presenting function in human dendritic cells via FcRIIa. Blood. 2008 May 15;111(10):5037-46
Bergsmedh, A, Ehnfors,J., Spetz, AL and Holmgren, L. A Cre-LoxP based system for studying horizontal gene transfer. FEBS Lett. 2007, 581:2943-6.
Behbahani, H., Walther-Jallow, L., Klareskog, E., French, A., Patterson, B.K., Garcia, P., Spetz, AL., Andersson, J. and Landay, A. Pro-Inflammatory and Type 1 Cytokine Expression in Cervical Mucosa During HIV-1 and HPV Infection.2007 J. of AIDS 45:9-19
Johansson, U., Walther-Jallow, L., Smed-Sörensen, A. and Spetz, AL. Triggering of Dendritic Cell Responses after Exposure to Activated, but not Resting, Apoptotic PBMCs. 2007 J. Immunol. 179:1711-20
Söderlund, J., Hirbod, T., Smed-Sörensen, A., Johansson, U., Kimani, J., Plummer, Spetz, AL., Andersson, J., Kaul, R., and Broliden, K. Plasma and mucosal fluid from HIV-1 infected patients but not from HIV-1 exposed uninfected subjects prevent HIV-1 exposed DC from infecting other target cells. AIDS Res and HUM Retroviruses, 2007, 1:101-6
Smed Sörensen, A., Loré, K., Mascola, J.R.., Ambrozak, D.R.., Andersson, J., Spetz, AL. and Koup, R.A.. Differential susceptibility to HIV-1 infection of myeloid and plasmacytoid dendritic cells. J. Virol. 2005, 79; 8861-9
Smed Sörensen, A., Lore, K., Walther-Jallow, L., Andersson, J., and Spetz, AL. HIV-1 infected dendritic cells up-regulate cell surface markers but fail to produce IL-12p70 in response to CD40 ligand stimulation. Blood, 2004,104;1-8
Spetz, A.-L. Lateral gene transfer in the genomic era. JCI. 2003, 116: 2821
Tjernlund, A., Fleener, Z., Behbahani, H., Connick, E., Sönnerborg, A., Broström, Goh, L., Spetz, AL., Patterson, B. and Andersson, J. Suppression of LIF in lymphoid tissue in primary HIV infection: absence of HIV replication in gp130-positive cells. AIDS, 2003. 17:1-8
Spetz, AL., Smed-Sörenssen, A., Andersson, J., Wahren, B., Holmgren, L., and Hinkula, J. Induction of HIV-1 Specific immunity in Mice after Vaccination with Apoptotic HIV-1/MuLV Pseudovirus Infected Syngeneic Cells. 2002 J.Immunol. 169;5771-9
Bergsmedh, A., Szelez, A., Spetz, AL. And Holmgren, L. Loss of the p21 (Cip1/Waf1) cyclin-kinase inhibitor results in propagation of horizontally transferred DNA. 2002 Cancer Res. 62;575-9
Holmgren, L., Bergsmedh, A., Spetz, A.-L. Horizontal transfer of DNA by the uptake of apoptotic bodies. Vox Sang. 2002 Aug;83 Suppl 1:305-6.
Andersson, A., Rauber, L., Kinloch, S., Sönnerborg, A., Nilsson, J., Fehniger, T.E., Spetz, AL., Behbahani, H., Goh, L.-E., McDade,H., Gazzard, B., Stellbrink, H., Cooper, D. and Perrin, L. Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during HIV-1 infection. 2002 J.Infect.Dis. 185; 1355-8
Bergsmedh,A., Szeles, A., Henriksson, M., Bratt, A., Folkman, J., Spetz, AL. and Holmgren, L. Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc. Natl. Acad. Sci. 2001. 98;6407-6411
Lore, K., Spetz, AL., Fehniger, T.E., Sonnerborg, A., Landay, A. and Andersson, J. Quantitative single cell methods that identify cytokine and chemokine expression in dendritic cells. 2001 J.Immunol Methods 249;207-222
Olsson, J., Poles, J., Spetz, AL., Eliott, M., Hultin,L., Giorgi, J., Andersson, A. And Anton, P. HIV-1 infection is associated with significant mucosal inflammation, characterised by increased expression of CCR5, CXCR4 and β-chemokines. 2000 J. Infect. Dis. 182; 1625-1635
Behbahani, H., Popek, E., Garcia, P., Andersson, A., Spetz, AL., Landay, A., Flener, Z. and Patterson, B. Upregulation of CCR5 expression in the placenta is associated with HIV-1 vertical transmission. 2000, Am.J.Pathol. 157; 1811-1818
Behbahani, H., Landay, A., Patterson, B., Jones, P., Pottage, J., Agnoli. M., Andersson, J, and Spetz, AL. Normalisation of immune activation in lymphoid tissue following potent antiretroviral therapy. 2000 JAIDS 25; 150-156
Spetz, AL., Patterson, B.K., Lore, K., Andersson, A. and Holmgren, L. Functional gene transfer of Human Immunodeficiency Virus type 1- DNA by a HIV-Receptor Independent Mechanism. 1999 J.Immunol. 163; 736-742
Lore, K., Sönnerborg, A., Spetz, A.-L., Andersson, U. and Andersson, J. Immunocytochemical detection of cytokines and chemokines in Langerhans cells and in vitro derived dendritic cells. 1998 J.Immunol.Method. 218; 173-187
Spetz, AL., Strominger, J.L. and Groh-Spies, V. T cell subsets in normal human epidermis. 1996 Am.J.Pathol. 149; 665-674
Bodor, J., Spetz, AL., Strominger, J.L. and Habener, J.F. cAMP inducibility of transcriptional repressor ICER in developing and mature T lymphocytes. 1996, Proc. Natl. Acad. Sci. 93; 3536-3541
Bodor, J., Walker, W., Flemington, E., Spetz, A.-L. and Habener, J.F. Modulation of Tax and PKA-mediated expression of HTLV-I promotor via cAMP response element binding and modulator proteins CREB and CREM. 1995 FEBS Letters, 377; 413-
Spetz, A.-L., Brenden, N., Pilström, B. and Böhme, J. A No evidence for TCR Vβ repertoire changes influencing disease protection in E-alpha transgenic NOD mice. 1995 Scand.J.Immunol. 42;135-139
Brenden, N., Spetz, A.-L., Pilström, B. and Böhme, J. Positive selection of Vβ 10 in NOD mice protected from diabetes by an Eα transgene. 1994. Immunol. Letters 42; 209-210
Spetz, A.-L., Casrouge, A., Cochet, M., Kourilsky, P. and Larsson-Sciard, E.-L. Co-expression of T cell receptor β and δ mRNA detected at high frequency in hybridomas derived from adult thymus. 1992 Scand.J.Immunol. 36; 167-175
Spetz, AL., Kourilsky, P. and Larsson-Sciard, E.-L. Induction of CD8 molecules on thymic γδ T cells in vitro is dependent upon αβ T cells. 1991 Eur.J.Immunol. 21;2755-2759
Larsson-Sciard, E.-L., Spetz-Hagberg, A.-L., Casrouge, A. and Kourilsky, P. Analysis of T cell receptor Vβ-usage in primary mixed lymphocyte reactions: evidence for directive usage by different antigen presenting cells and Mlsa determinants on T cell blasts. 1990 Eur.J.Immunol. 20;1223-1229
Spetz-Hagberg, AL., Goldschmidt, T.J., Stålhandske, T. and Larsson-Sciard, E.-L. Amelioration of intrathymic T cell development and peripheral T cell reactivities in autoimmune mice undergoing therapy with a novel immunomodulator. 1990 Int.Immunol. 2:7;645-650
Spetz-Hagberg, A.-L. and Larsson-Sciard, E.-L. Decreased levels of pathogenic IgG anti-DNA antibodies in autoimmune MRL-lpr mice after Linomide treatment. 1989 Res.Immunol. 140;517-525
Kourilsky, P., Claverie, J.M., Prochnicka-Chalufour, A., Spetz-Hagberg, A.-L. and Larsson-Sciard, E.-L. How important is the direct recognition of polymorphic MHC residues by TcR in the generation of the T cell repertoire? (1989) Quant.Biol.Cold Spring Harbor Vol.LIV; 93-103
