The research primarily focuses on understanding how mammalian cells maintain genomic stability and by which mechanisms low doses of gamma radiation, UV radiation and certain chemicals destabilise the genome. The focus is on nucleotide pool imbalance and oxidation. There are strong inter-individual variations among humans regarding the maintenance of genomic stability and response to toxic agents which could be due to the genetic background and life style factors. Understanding the underlying mechanisms that make some individuals sensitive to UV and ionizing radiation or chemicals is very important for estimating individual risk of cancer, diabetes complications, cardiovascular and other age-related diseases.
Keywords: Oxidative stress, genomic instability, nucleotide pool imbalance, MTH1, individual radiation sensitivity, DNA damage, DNA repair
Selected publications
N. Rey, T. Ebrahimian, C. Gloaguen, D. Kereselidze, V. Magneron, C. A. Bontemps, C. Demarquay, G. Olsson, S. Haghdoost, S. Lehoux, and Teni G. Ebrahimian, Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and U-curved Response of T Cells in APOE -/- Mice, Dose-Response: April-June 2021:1-9
Kimi Drobin, Michal Marczyk, Martin Halle, Daniel Danielsson, Anna Papiez, Traimate Sangsuwan, Annika Bendes, Mun-Gwan Hong, Ulrika Qundos, Mats Harms-Ringdahl, Peter Wersäll, Joanna Polanska, Jochen M. Schwenk and Siamak Haghdoost,* Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer, Cancers 2020, 12, 753
Paulo Roberto D'Auria Vieira de Godoy, Ayumi Nakamura, Ali Pour Khavari, Traimate Sangsuwan, Siamak Haghdoost, Effect of dose and dose rate of gamma irradiation on the formation of micronuclei in bone marrow cells isolated from whole-body-irradiated mice, Environ Mol Mutagen. 2021;62:422-427
Paulo R. D. V. Godoy, Ali Pour Khavari, Marzia Rizzo, Elza T. Sakamoto-Hojo and Siamak Haghdoost, Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress, Oxidative Medicine and Cellular Longevity Volume 2020
Ali Pour Khavari and Siamak Haghdoost, Effects of Tomato Juice Intake on Salivary 8-Oxo-dG Levels as Oxidative Stress Biomarker after Extensive Physical Exercise, Oxidative Medicine and Cellular Longevity Volume 2020
Dietrich Averbeck, Serge Candeias, Sudhir Chandna, Nicolas Foray, Anna A. Friedl,
Siamak Haghdoost, Penelope A. Jeggo, Katalin Lumniczky, Francois Paris, Roel Quintens, and Laure Sabatier, Establishing mechanisms affecting the individual response to ionizing radiation, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 2020, VOL. 96, NO. 3, 297–323
