Transcriptional control of Drosophila embryo development
Creation of different cell types from an identical DNA sequence is one of the most remarkable properties of genomes, and a fundamental question in developmental biology. Control of transcription establishes the gene expression programs that define a cell and directs cell differentiation. It is thereby critical for embryo development. A mechanistic view of transcriptional regulation is not only necessary for recognition of how specific cell states are established and epigenetically maintained, but also for understanding how its misregulation leads to disease. The Drosophila embryo allows us to dissect these mechanisms in vivo by a set of tools that are not readily available elsewhere. Molecular, genetic, and genomic approaches are used to identify the molecular mechanisms by which tissue-specific gene expression is controlled in vivo.
transcription, co-regulators, genome-wide, chromatin, epigenetics, embryo patterning
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Holmqvist, P.H., Boija, A., Philip, P., Crona, F., Stenberg, P., & Mannervik, M. (2012). Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos. PLoS Genetics. 8(6):e1002769
Nègre, N., Brown, C.D., Ma, L., Bristow, C.A., Miller, S.W., Wagner, U., Kheradpour, P., Eaton, M.L., Loriaux, P., Sealfon, R., Li, Z., Ishii, H., Spokony, R.F., Chen, J., Hwang, L., Cheng, C., Auburn, R.P., Davis, M.B., Domanus, M., Shah, P.K., Morrison, C.A., Zieba, J., Suchy, S., Senderowicz, L., Victorsen, A., Bild, N.A., Grundstad, A.J., Hanley, D., MacAlpine, D.M., Mannervik, M., Venken, K., Bellen, H., White, R., Gerstein, M., Russell, S., Grossman, R.L., Ren, B., Posakony, J.W., Kellis, M., & White, K.P. (2011). A cis-regulatory map of the Drosophila genome. Nature. 471(7339):527-31
Qi, D., Bergman, M., Aihara, H., Nibu, Y., &Mannervik, M. (2008). Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation. EMBO J. 27(6):898-909
Haecker, A., Qi, D., Lilja, T., Moussian, B., Andrioli, L.P., Luschnig, S., & Mannervik, M. (2007). Drosophila Brakeless Interacts with Atrophin and is Required for Tailless-Mediated Transcriptional Repression in Early Embryos. PLoS Biology. 5, 1298-1308
(Link to ORCID)
February 22, 2016
Page editor: Elin Eriksson
Source: Department of Molecular Biosciences, The Wenner-Gren Institute