DNA Research

On this page we collect articles about DNA Research.

Ledigt jobb CPG. Foto: Jens Olof Lasthein.

News

2023-03-08

Aspirin protects against genotoxicity by promoting genome repair

Acetylsalicylic acid (aspirin) is arguably the oldest drug in the history of medicine. In a study published in Cell Research, researchers at Stockholm University and the University Medical Center Freiburg, have identified a new mechanism of aspirin. They show that aspirin promotes genome repair and can protect mice and cells against the toxic effects of irradiation and mutagenic chemicals. This new mechanism may help explain many of the health benefits of aspirin including cancer prevention.

2023-03-06

Mysterious genes may explain the origin of species

Why are the offspring of a horse and a donkey almost always infertile? This question has long puzzled researchers. Deniz Ozata, from Stockholm University, believes the explanation may lie in very mutable genes that are vital to the development of healthy sperm.

DNA Research Life Science Plants, Animals and Nature

Arkeologiska utgrävningar av Sandby borg på Öland.

2023-01-06

DNA from archaeological remains show exceptional migration to Scandinavia during the Viking era

A new study based on 297 ancient Scandinavian genomes analysed together with the genomic data of 16,638 present day Scandinavians resolve the complex relations between geography, ancestry, and gene flow in Scandinavia – encompassing the Roman Age, the Viking Age and later periods. A surprising increase of variation during the Viking period indicates that gene flow into Scandinavia was especially intense during this period.

DNA Research History, Archeology and Cultural Heritage SciLifeLab

2022-12-21

Stockholm University Baltic Sea Centre

Five options for restoring global biodiversity after the UN agreement

To slow and reverse the fastest loss of Earth’s living things since the dinosaurs, almost 200 countries have signed an agreement in Montreal, Canada, promising to live in harmony with nature by 2050. The Kunming-Montreal agreement is not legally binding but it will require signatories to report their progress towards meeting targets such as the protection of 30% of Earth’s surface by 2030 and the restoration of degraded habitats.

Oceans and Lakes Plants, Animals and Nature Climate and Environment DNA Research

Deciphering cell diversity in the brain by probing diverse epigenetic information simultaneously in single cells: Nano CUT&tag takes advantage of modified nanobodies, fragments of antibodies occurring in camelids such as alpacas, to map histone modifications in thousands of individual cells in the mouse brain. Illustration by Amagoia Agirre.

2022-12-21

Department of Biochemistry and Biophysics

Simultaneous mapping of several different epigenetic landmarks in a single cell

Researchers at Karolinska Institutet had in 2021 developed a technique making possible to examine how different versions of histones bind to the genome in tens of thousands of individual cells. Now the same team developed a new technology allowing simultaneous probing of several different histone marks in one individual cell and in thousands of cells at the same time. This new method allows to investigate in much greater detail how cells in the mouse brain acquire unique properties and specialize. The study is published in the journal Nature Biotechnology.

DNA Research Health and Living Conditions

2022-12-08

Department of Biochemistry and Biophysics

New method for mapping cancer paves the way for treatment of incurable brain cancer in children

Children diagnosed with brain cancer often die within a year of their initial diagnosis because there are no effective treatments for this rare form of cancer. But by visualizing the cancer cells, researchers have now gained a better understanding of what the tumors look like. The hope is that it will lead to new treatment methods. This is shown by a study with researchers at, among others, Stockholm University and SciLifeLab, recently published in Nature Genetics.

DNA Research Health and Living Conditions SciLifeLab Life Science

Research groups

Group Dai

Regulation of cell fate decision is fundamental to development, disease, and regeneration. We address how gene regulatory systems guide the assembly of complex biological patterns by investigating stem cell biology and cell fate decision mechanisms.

Group Emami

We work on infectious-disease biology with a focus on host-pathogen-vector signalling-communication. We provide a fundamental/quantitative description of communication in infection-biology/behaviour plasticity, and genetics towards the design of novel scientific technologies.

Group Engström

We study gene expression with a focus on the role of POU/Oct transcription factors in development, stem cell regulation, cancer and immunity. We use the fruitfly Drosophila as a model organism and utilize the genetic tools developed for this organism, in combination with high-throughput expression analyses, high resolution microscopy and live-cell imaging.

Group Faye

Our aim is to study the effects of bacterial phosphoantigens (HMBPP and IPP) on appetite. We introduced these into mice by gavage and followed the differences in weight gain and gene transcription from relevant tissues. An unexpected effect on male salivary glands focused our interest also on their effects on immune response.

Group Friedländer

Our group applies computational and omics methods to study mammalian transcriptome regulation, with special emphasis on microRNAs.

Group Gekara

The immune system that kills disease-causing microbes and heals tissues, and the DNA repair system that maintains gene expression are essential for life. However, they require careful regulation to prevent the destruction of own tissues. The goal of my research is to better understand these systems and find new strategies in the treatment of diseases.