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Research group Group Engström

We study gene expression with a focus on the role of POU/Oct transcription factors in development, stem cell regulation, cancer and immunity. We use the fruitfly Drosophila as a model organism and utilize the genetic tools developed for this organism, in combination with high-throughput expression analyses, high resolution microscopy and live-cell imaging.

Group description

The webpage is under construction.

Group members

Group managers

Ylva Engström

Professor

Department of Molecular Biosciences, The Wenner-Gren Institute

08-16 41 66

ylva.engstrom@su.se

Members

Adam Majer

Student

Department of Molecular Biosciences, The Wenner-Gren Institute

adam.majer@su.se

Laiwan Harring

Student

Department of Molecular Biosciences, The Wenner-Gren Institute

laiwan.harring@su.se

Alejandra Escós

Postdoc

Department of Molecular Biosciences, The Wenner-Gren Institute

alejandra.escos@su.se

Georg Wolfstetter

Researcher

Department of Molecular Biosciences, The Wenner-Gren Institute

georg.wolfstetter@su.se

Laveena Kansara

PhD student

Department of Molecular Biosciences, The Wenner-Gren Institute

laveena.kansara@su.se

Vasilios Tsarouhas

Researcher

Department of Molecular Biosciences, The Wenner-Gren Institute

08-16 14 79

08-16 32 74

vasilios.tsarouhas@su.se

Publications

Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila

development. Zhao Y, Lindberg BG, Esfahani SS, Tang X, Piazza S, Engström Y. BMC Biol. 2021 Sep 3;19(1):185. doi: 10.1186/s12915-021-01106-0. PMID: 34479564

Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development.

Duan J, Zhao Y, Li H, Habernig L, Gordon MD, Miao X, Engström Y, Büttner S. Cell Rep. 2020 Jul 28;32(4):107972. doi: 10.1016/j.celrep.2020.107972. PMID: 32726635

The POU/Oct Transcription Factor Nubbin Controls the Balance of Intestinal Stem Cell Maintenance and

Differentiation by Isoform-Specific Regulation. Tang X, Zhao Y, Buchon N, Engström Y. Stem Cell Reports. 2018 May 8;10(5):1565-1578. doi: 10.1016/j.stemcr.2018.03.014. Epub 2018 Apr 19. PMID: 29681543 .

Nubbin isoform antagonism governs Drosophila intestinal immune homeostasis.

Lindberg BG, Tang X, Dantoft W, Gohel P, Seyedoleslami Esfahani S, Lindvall JM, Engström Y. PLoS Pathog. 2018 Mar 2;14(3):e1006936. doi: 10.1371/journal.ppat.1006936. eCollection 2018 Mar. PMID: 29499056

The POU/Oct Transcription Factor Pdm1/nub Is Necessary for a Beneficial Gut Microbiota and Normal

Lifespan of Drosophila. Dantoft W, Lundin D, Esfahani SS, Engström Y. J Innate Immun. 2016;8(4):412-26. doi: 10.1159/000446368. Epub 2016 May 28. PMID: 27231014.

The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the

tolerance to gut microbiota. Dantoft W, Davis MM, Lindvall JM, Tang X, Uvell H, Junell A, Beskow A, Engström Y. BMC Biol. 2013 Sep 6;11:99. doi: 10.1186/1741-7007-11-99. PMID: 24010524.

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News

2022-11-10

Department of Molecular Biosciences, The Wenner-Gren Institute

Discovery of a neural circuit for sweet and bitter taste

Yunpo Zhao, Jianli Duan and Ylva Engström, together with collaborators in the US, have discovered that a cluster of neurons control sugar and bitter sensitivity in the fruit fly Drosophila. These neurons originate from the same neural stem cell and use the inhibitory neurotransmitter GABA to control taste sensation.

Life Science