Stockholm university

SciLifeLab

SciLifeLab - a hub for advanced life sciences.

SciLifeLab is a national research infrastructure based in Stockholm and Uppsala. Here, internationally recognized research in life science is conducted by several research groups from Stockholm University.

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Foto: Camilla Breiler

News

The Faculty of Science announces 10 PhD positions

As a PhD student at Stockholm University, you will have the opportunity to deepen your knowledge in a subject area, ask important questions, and contribute to new knowledge. 10 PhD positions are now available in science.

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Department of Molecular Biosciences, The Wenner-Gren Institute

Morteza Aslanzadeh - A short interview before the defense

On August 22, Morteza Aslanzadeh will publicly defend his doctoral thesis, Exploring the Biology of Non-Coding RNAs: From Gene Regulation to Evolutionary Perspectives. The defense will take place at Gamma 2 at SciLifeLab, and all are warmly welcome to attend. We have had a short interview with Morteza before the defense.

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Portraits of the researchers Martin Jastroch, Hanna Johannesson and David Drew.

Three ERC Advanced Grants to researchers at Stockholm University

Martin Jastroch, Hanna Johannesson and David Drew at Stockholm University are awarded Advanced Grants by the European Research Council ERC. In total, it is about SEK 86 million for research in evolutionary biology, biochemistry and molecular bioscience.

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Department of Environmental Science

The power behind big data: high-performance computing in environmental toxicogenomics

What happens when cutting-edge biology meets powerful computing? At the Department of Environmental Science, researchers are harnessing the power of high-performance computing (HPC) to investigate how pollution leaves its mark—not only on individuals, but on future generations.

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Department of Biochemistry and Biophysics

Scientists reveal how energy is delivered into the cells major “shipping port”

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy transport could affect diseases such as type 2 diabetes, cancer, and neurodegenerative disorders. The study, published in Nature, confirms that the transporter protein SLC35B1 is the key gateway for ATP entry into the ER.

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Department of Ecology, Environment and Plant Sciences

DEEP seeks Associate Professor in Plant Molecular Physiology – apply now!

The Department of Ecology, Environment and Plant Sciences (DEEP) at Stockholm University is inviting applications for a tenured Associate Professor position in Plant Molecular Physiology. Situated in Sweden’s dynamic capital, the university offers a world-class research environment where education and research thrive together.

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Department of Biochemistry and Biophysics

Birds and mammals build advanced brain circuits using different developmental mechanisms

The area in the brain responsible for complex cognitive functions have different origin in different species such as mammals, birds, and reptiles new research show. These findings indicate that these structures and circuits are not homologous, but rather the result of convergent evolution.

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Tanja Slotte receives funding from the Knut and Alice Wallenberg Foundation

Each year, the Knut and Alice Wallenberg Foundation awards research grants in the fields of medicine, science, and technology to research projects that are judged to have such high scientific potential that they are likely to lead to future scientific breakthroughs. Each project is evaluated by a group of international experts in the respective field.

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Jan Ellenberg appointed Director for SciLifeLab

The SciLifeLab board has appointed Professor Jan Ellenberg as the new Director. Alongside this role, Professor Ellenberg will also be appointed as a Professor at Karolinska Institutet and Affiliated Professor at Stockholm University and KTH Royal Institute of Technology. He succeeds Professor Olli Kallioniemi, who has served as SciLifeLab Director since 2015.

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Department of Environmental Science

New study reveals transgenerational effects of pesticide linuron on frogs

Grand-offspring of male frogs exposed to the pesticide linuron exhibited changes in their DNA that was linked to significant physiological impacts, a study from Stockholm University reveals. The research highlights the profound transgenerational consequences of environmental pollution on amphibian populations, which are already under threat of extinction. The study is published in the journal Science of the Total Environment.

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Iskra följer forskare som jobbar med mikroskop
Department of Biochemistry and Biophysics

Mapping the brain's serotonin pathways increases knowledge of our emotions

Fear and curiosity are emotions that determine how adventurous or cautious we are. But how are our emotions controlled by biological factors in the brain's nerve cells? New research shows that clearly defined serotonin pathways in the brain and their connections to for example amygdala and hypothalamus affect how we feel and act.

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Department of Environmental Science

Environmental Science Research Day 2024: A call to arms for academia and activists alike

In an ambitious gathering of 170 participants, organized by the Department of Environmental Science and the Bolin Centre for Climate Research, the Aula Magna auditorium played host to the Environmental Science Research Day on 1 February 2024.

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Department of Environmental Science

Scientists to unveil how chemical exposure can affect generations to come

Research led by Oskar Karlsson, Assistant Professor at the Department of Environmental Science, aims to shed light on the long-term effects of chemical exposure across generations. Karlsson's team is tackling the daunting task of safeguarding human health against an estimated 350,000 chemicals in the market, a figure likely on the lower side.

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Arkeologiska utgrävningar av Sandby borg på Öland.

DNA from archaeological remains show exceptional migration to Scandinavia during the Viking era

A new study based on 297 ancient Scandinavian genomes analysed together with the genomic data of 16,638 present day Scandinavians resolve the complex relations between geography, ancestry, and gene flow in Scandinavia – encompassing the Roman Age, the Viking Age and later periods. A surprising increase of variation during the Viking period indicates that gene flow into Scandinavia was especially intense during this period.

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Department of Biochemistry and Biophysics

New method for mapping cancer paves the way for treatment of incurable brain cancer in children

Children diagnosed with brain cancer often die within a year of their initial diagnosis because there are no effective treatments for this rare form of cancer. But by visualizing the cancer cells, researchers have now gained a better understanding of what the tumors look like. The hope is that it will lead to new treatment methods. This is shown by a study with researchers at, among others, Stockholm University and SciLifeLab, recently published in Nature Genetics.

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Department of Biochemistry and Biophysics

Basic research for the benefit of ALS patients

By understanding why certain nerve cells and the muscles they control are resistant to fading in the deadly disease ALS, it is possible to create new possibilities for treatments. Researchers at Stockholm University are now trying to identify and transfer the properties of these resistant nerve cells.

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Photo: Hyunho Kim

Mapping energy conversion in cells

Billions of years of evolution are behind the ingenious protein machinery in nature’s cells, which captures and converts energy. Professor Ville Kaila is conducting a detailed study of the structure and function of the proteins to learn more about the energy conversion process. That knowledge may eventually result in therapies for diseases where the powerhouses of the cells fall short.

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Events

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Research projects

Argonaute TRIBE

Antibody-based methods such as CLIP can detect direct interactions between microRNAs and their mRNA targets in cell populations with nucleotide resolution. However, these methods typically require millions of cells, and cannot be applied to study the single cells where the interactions occur.

Cell Biology of nutrient regulated gene expression

Proteins with multiple membrane-segments (MS) initially insert into the endoplasmic reticulum (ER) of eukaryotic cells. Little is known how such proteins attain native functional structures. We study the ER membrane chaperone Shr3 that specifically facilitates the folding of all 18 members of the yeast amino acid permease family of proteins with 12 MS.

Research
Ecosystem mapping in the Central Arctic Ocean

The marine ecosystem around the North Pole, the Central Arctic Ocean (CAO), is in fast transition from a permanently to a seasonally ice-covered ocean as a result of global warming. The sea-ice loss will enable summer access to the CAO for non-icebreaking ships, including fishery vessels, in the near future and this project is assessing the impact.

Establishment of epigenetic landscapes

Epigenetic patterns of histone modifications contribute to the maintenance of tissue-specific gene expression, but little is known about how such patterns are initially formed during early embryo development. We study this process and how cell type-specific patterns emerge in Drosophila.

Metabolic regulation and spatio-temporal aspects of fungal virulence in situ

Amino acids are essential nutrients that serve as building blocks of proteins and some are efficiently metabolized for energy. Eukaryotic cells respond to extracellular amino acids by enhancing their uptake. We study the molecular mechanisms underlying this response and the role of amino acid metabolism in promoting virulent growth of human fungal pathogens.

Paleotranscriptomics

Today, sequencing of DNA from ancient samples is a standard method in Paleogenomics, however, RNA is generally unstable due to the ubiquitous presence of RNases in the environment.

Research
SeaLab

SeaLab is a joint research venture between the Baltic Sea Centre at Stockholm University and the Environmental Genomics group at SciLifeLab. By combining biogeochemical, ecological, molecular and meta-omic expertise and know-how, the aim is to understand the fundamental microbial processes of coastal ecosystems.

Undervattensbild med blåstång där ytan och land skymtar.
The importance of the MEP pathway in the microbiome and its effect on behavior

Our main aim is to study the effects of bacterial phosphoantigens (HMBPP and IPP) on appetite. We introduced these into mice by gavage and followed the differences in weight gain and gene transcription from relevant tissues. An unexpected effect on male salivary glands focused our interest also on their effects on immune response.

Research
Transcription, coregulators and histone acetylation

Gene transcription is essential for cell identity and its misregulation causes disease. This project explores the connection between transcription and chromatin modifications that make genes accessible to the transcriptional machinery.

Research
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Research groups

Arne Elofsson's research group

Combining large scale life-science data with artificial intelligence is crucial for the continued progression of our understanding of the molecular processes that govern life. We propose developing novel deep-learning methods to provide an unprecedented accurate description of the human proteome.

Arne Elofsson
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Clouds, airborne particles and gases

A continued change in the atmospheric content of greenhouse gases and particles is estimated to result in future warming well above 1.5°C, compared with pre-industrial levels. It is uncertain how much heating is masked by the cooling effect of the particles, especially the effect of the particles on the distribution and properties of the clouds.

Clouds. Photo: Marianne Lagerklint/MISU/Stockholm University
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David Drew's research group

The Drew group investigates the alternating-access mechanism of solute transporters for sugars and ions. These transporters are critical to cell homeostasis and their dysfunction is associated with human diseases, such as cancer and diabetes.

David Drew
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Emil Marklund's research group

In our lab we investigate how biological macromolecules can manage to interact with each other with high specificity, and how sequence information determines macromolecular structure and function.

profile_emil
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Erik Lindahl's research group

Our research is focused on understanding the doors and windows of our cells in the form of membrane proteins in general, and in particular the functions of ion channels and pumps that transport ions to make our nervous system work.

Erik Lindahl
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Erik Sonnhammer's research group

We are only starting to understand the functional networks of the proteins encoded in the now sequenced human genome. The group is addressing this issue using computational approaches, such as hidden Markov models, evolutionary models, and discriminant statistical methods - aiming to predict function, both with regards to biochemical activity and pathways.

Erik Sonnhammer
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Group Bryant

We aim to create a universal molecular framework, where any molecule can be predicted with AI. With this technology, the design of new molecules will be possible at the click of a button – for any application.

Fotograf: Patrick Bryant
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Group Emami

We work on infectious-disease biology with a focus on host-pathogen-vector signalling-communication. We provide a fundamental/quantitative description of communication in infection-biology/behaviour plasticity, and genetics towards the design of novel scientific technologies.

Noushin Emami
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Group Faye

Our aim is to study the effects of bacterial phosphoantigens (HMBPP and IPP) on appetite. We introduced these into mice by gavage and followed the differences in weight gain and gene transcription from relevant tissues. An unexpected effect on male salivary glands focused our interest also on their effects on immune response.

Ingrid Faye
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Group Jonas

Our group studies how bacteria grow and reproduce in fluctuating environments. We use a combination of genetics, cell biology and biochemistry to dissect the molecular mechanisms underlying bacterial growth and cell cycle progression and how these processes are regulated under changing environmental conditions to ensure bacterial survival.

Kristina Jonas
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Group Ljungdahl

Amino acids are essential nutrients that serve as building blocks of proteins and some are efficiently metabolized for energy. Eukaryotic cells respond to extracellular amino acids by enhancing their uptake. We study the molecular mechanisms underlying this response and the role of amino acid metabolism in promoting virulent growth of human fungal pathogens.

Per Ljungdahl
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Group Piazza

We’re fascinated by how metabolism influences gene expression. In our lab, we study how small molecules and metabolites can regulate what genes are turned on or off, and how this affects protein production. Our goal is to understand the molecular “language” that connects a cell’s metabolic state to its genetic activity.

Foto Illaria Piazza
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Group Samakovlis

Branched tubular organs are found in most animals. They include tissues like the lung, kidney and the vascular system. Many of the basic principles of tube construction in these organs are conserved among species. We aim to describe the genetic programs leading to the formation of a functional epithelial tubular network.

Christos Samakovlis
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Group Theopold

We regret to inform that our beloved colleague Ulrich Theopold passed away in end of September 2023. All our thoughts go out to his family. 

Ulrich Theopold
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Group Visa

Our research aims at understanding the mechanisms by which RNA and RNA degradation by the exosome contribute to chromatin regulation, gene expression and genome integrity.

Neus Visa
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Iskra Pollak-Dorocics research group

The immense complexity of the brain emerges from its vast connectivity and cell type diversity. We study the diversity of neuromodulatory neurons and circuits in the brain. By using a combination of molecular and system neuroscience tools to visualize, record and manipulate neural populations, we aim to understand their particular contribution to behavior.

Iskra Pollak Dorocic
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Juliette Griffie's research group

The Computational Microscopy for Cell Biology (CMCB) laboratory is a multidisciplinary team developing cutting-edge image analysis strategies to answer fundamental biology questions with advanced light microscopy.

Juliette Griffie
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Marta Carroni's research group

In our group, we use mainly cryo-EM to discover molecular regulatory mechanisms. We combine the technique also with cryogenic electron tomography (cryo-ET) and work at developing combinatory methods with fluorescence microscopy. We follow two main lines of research.

Marta Carroni
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Mats Nilsson's research group

Our work is focused on the development of novel molecular analysis concepts for research and diagnostics, focused on infectious and cancer diagnostics. Our approach is interdisciplinary, spanning from physics to clinical research, with the goal of providing industrial products available to the scientific community and hospital laboratories.

Mats Nilsson
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Milka Doktorova's research group

The Cell Membrane Biophysics Lab (CMBL) is a dynamic research lab that delves into the biophysics of cell membranes – decoding their organization, structure and function through a powerful blend of computer simulations, theoretical insights and experimental techniques.

Milka Doktorova
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Samuel Flores' research group

What do we do once the world's genomes have been sequenced? There is still the question of what these molecules look like once they are transcribed into RNA (we work on this) and from there translated to protein (where Google's AlphaFold has made great progress) and what they do in the cell. 

Samuel Flores
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