We study how cells safeguard health and aging by maintaining their proteomes functional. Our research develops fundamental insight into the mechanisms of the proteostasis system.

Our team studies the biology underlying malaria transmission, with the ultimate goal of enabling novel strategies to hamper the spread of the disease

We explore how cells maintain genome stability using yeast cells as a model. Specifically, we investigate repetitive DNA such as telomeres and the rDNA loci. We are interested in both telomere maintenance and DNA repair mechanisms.

Our current research on the pathobiology of parasitic infections integrates molecular parasitology with immunology and cell biology to understand how obligate intracellular parasites interact with the host.

Obesity is a major inducer of type II diabetes and it is estimated by the World Health Organization that over 500 million people worldwide suffer from either of these disorders, with the incidence increasing dramatically over the last 10 years.

We aim to create a universal molecular framework, where any molecule can be predicted with AI. With this technology, the design of new molecules will be possible at the click of a button – for any application.

We study how different organelles within a cell communicate and how this interorganellar connectivity contributes to protein homeostasis and cellular fitness during aging.

Regulation of cell fate decision is fundamental to development, disease, and regeneration. We address how gene regulatory systems guide the assembly of complex biological patterns by investigating stem cell biology and cell fate decision mechanisms.

We explore the intricate relationship between genetics and environmental factors in shaping offspring health. By studying germline development, placental function, and the impact of early-life exposures, we aim to uncover how parental health influences disease risk across generations.

We work on infectious-disease biology with a focus on host-pathogen-vector signalling-communication. We provide a fundamental/quantitative description of communication in infection-biology/behaviour plasticity, and genetics towards the design of novel scientific technologies.

We study gene expression with a focus on the role of POU/Oct transcription factors in development, stem cell regulation, cancer and immunity. We use the fruitfly Drosophila as a model organism and utilize the genetic tools developed for this organism, in combination with high-throughput expression analyses, high resolution microscopy and live-cell imaging.

Our aim is to study the effects of bacterial phosphoantigens (HMBPP and IPP) on appetite. We introduced these into mice by gavage and followed the differences in weight gain and gene transcription from relevant tissues. An unexpected effect on male salivary glands focused our interest also on their effects on immune response.

Our group applies computational and omics methods to study mammalian transcriptome regulation, with special emphasis on microRNAs.

The immune system that kills disease-causing microbes and heals tissues, and the DNA repair system that maintains gene expression are essential for life. However, they require careful regulation to prevent the destruction of own tissues. The goal of my research is to better understand these systems and find new strategies in the treatment of diseases.

The research primarily focuses on understanding how mammalian cells maintain genomic stability and by which mechanisms low doses of gamma radiation, UV radiation and certain chemicals destabilise the genome.

We investigate the physiology and molecular mechanisms of energy metabolism from the organism to the molecule. We focus on metabolic aspects during obesity, adipose tissue biology, mitochondrial mechanisms and thermogenesis.

Our group studies how bacteria grow and reproduce in fluctuating environments. We use a combination of genetics, cell biology and biochemistry to dissect the molecular mechanisms underlying bacterial growth and cell cycle progression and how these processes are regulated under changing environmental conditions to ensure bacterial survival.

Bacterial infection and host defence.

The main focus of our research group is to understand how endocrine crosstalk, involving adipose tissue, controls mammalian energy metabolism. Our goal is to identify target mechanisms for novel therapeutic strategies to fight obesity.

Amino acids are essential nutrients that serve as building blocks of proteins and some are efficiently metabolized for energy. Eukaryotic cells respond to extracellular amino acids by enhancing their uptake. We study the molecular mechanisms underlying this response and the role of amino acid metabolism in promoting virulent growth of human fungal pathogens.

We study transcriptional control of embryo development using cutting-edge genomic technologies and advanced Drosophila genetics.

Nonshivering thermogenesis emanates from the activity of the mitochondrial protein UC P1 in brown adipose tissue. We use novel model systems to advance the understanding of mammalian thermogenesis.

Our lab studies the functional role of chromatin changes and non-coding RNAs in gene regulation; in the regulation of ribosomal transcription in response to cellular states and in the regulation of the human immune response to pathogens.

As a new research group aiming to construct an international work environment with a mutual respect, our main objective is to enthusiastically investigate how a mammalian male germ cell commits to become a functional sperm. Our studies will therefore advance our understanding of sperm development and may suggest approaches to promote fertility.

Aging is a strong determinant of human health and longevity. We study the molecular mechanisms that regulate aging, aiming to eventually target them for therapeutic purposes.

Branched tubular organs are found in most animals. They include tissues like the lung, kidney and the vascular system. Many of the basic principles of tube construction in these organs are conserved among species. We aim to describe the genetic programs leading to the formation of a functional epithelial tubular network.

Roger Karlsson's research reflects a long-standing interest in eukaryotic cell motility, i.e. movements of intracellular structures and migration of whole cells.

We are exploring basic mechanisms regarding a group of small non-coding oligonucleotides and their therapeutic potential. We have discovered that a set of single-stranded oligonucleotides temporarily inhibit certain endocytic pathways and thereby modulate innate immune responses as well as providing anti-viral effects.

We study host-microbe interactions and mechanisms that influence immune characteristics and functionality.

We regret to inform that our beloved colleague Ulrich Theopold passed away in end of September 2023. All our thoughts go out to his family. 

Our research aims at understanding the mechanisms by which RNA and RNA degradation by the exosome contribute to chromatin regulation, gene expression and genome integrity.

We are interested in biological and physical factors affecting cellular and molecular effects of ionising radiation. Focus is on DNA damage and repair, chromatin structure, low doses, low dose rates, mixed radiation qualities, fractionation and modulation by chemical and physical factors.