Research group Group Spetz
We are exploring basic mechanisms regarding a group of small non-coding oligonucleotides and their therapeutic potential. We have discovered that a set of single-stranded oligonucleotides temporarily inhibit certain endocytic pathways and thereby modulate innate immune responses as well as providing anti-viral effects.
Group description
The innate immune system is rapidly responding to defend against incoming pathogens, but also has to be balanced to avoid unwanted autoimmune reactions. We have discovered a pool of small non-coding single-stranded oligonucleotides with capacity to dampen signaling from endosomes containing TLR3,7, or 4. In addition, these oligonucleotides provide antiviral effects by inhibiting binding and/or entry of several viral families. We are now mapping local immune responses in the lungs and in the skin after treatment with a drug candidate non-coding oligonucleotide.
Group members
Group managers
Anna-Lena Spetz
Professor
Members
James Trumbo
Phd student
Kahkashan Kamal
PhD student