Stockholm university

Research group Group Spetz

We are exploring basic mechanisms regarding a group of small non-coding oligonucleotides and their therapeutic potential. We have discovered that a set of single-stranded oligonucleotides temporarily inhibit certain endocytic pathways and thereby modulate innate immune responses as well as providing anti-viral effects.

Group description

The innate immune system is rapidly responding to defend against incoming pathogens, but also has to be balanced to avoid unwanted autoimmune reactions. We have discovered a pool of small non-coding single-stranded oligonucleotides with capacity to dampen signaling from endosomes containing TLR3,7, or 4. In addition, these oligonucleotides provide antiviral effects by inhibiting binding and/or entry of several viral families. We are now mapping local immune responses in the lungs and in the skin after treatment with a drug candidate non-coding oligonucleotide.

Group members

Group managers

Anna-Lena Spetz

Professor

Department of Molecular Biosciences, The Wenner-Gren Institute
Anna-Lena Spetz

Members

James Trumbo

Phd student

Department of Molecular Biosciences, The Wenner-Gren Institute
James Trumbo

Kahkashan Kamal

PhD student

Department of Molecular Biosciences, The Wenner-Gren Institute
Kahkashan Kamal

Research projects

Publications

News