Stockholm university

Research group Group Sverremark-Ekström

We study host-microbe interactions and mechanisms that influence immune characteristics and functionality.

Group description

Our immune system gradually matures during the first year(s) of life under the influence of various environmental exposures. A prominent environmental factor in this context, is the gut microbiota. The molecular interactions between the early microbiota and the host promote immune development and maturation. Disturbances during this early process generating microbial deprivation/deviation, could result in poor infant immune maturation and/or altered immune balance, with an increased risk of immune-mediated disease later in life. 

Our main research goals are to understand biological mechanisms behind (gut) microbe-induced immune modulation. We investigate different mechanisms in the gut microbe-host cross-talk, including detailed analyses of exposed immune cells at DNA, RNA and protein levels but also which microbial factors that are involved. Further, we examine how these early events contribute to the development of immune mediated diseases like allergy and how immunotherapy influence the gut-immune interactions. We also aim to understand how the microbiota contributes to chemotherapy efficacy and toxicity as well as to the recovery of immune functions after cancer treatment. We perform cellular and molecular experimental studies in vitro, complemented by in vivo studies and work with human clinical samples.
 

Group members

Group managers

Eva Sverremark Ekström

Professor

Department of Molecular Biosciences, The Wenner-Gren Institute
Eva Sverremark Ekström_HT24

Members

Claudia Arasa Cuartiella

PhD student

Department of Molecular Biosciences, The Wenner-Gren Institute
Claudia Arasa Cuartiella

Isabella Badolati

PhD student

Department of Molecular Biosciences, The Wenner-Gren Institute
Isabella Badolati

Karolina Bucaro Stenman

PhD Student

Department of Molecular Biosciences, The Wenner-Gren Institute
Karolina Bucaro Stenman

Ymke de Jong

PhD student

Department of Molecular Biosciences, The Wenner-Gren Institute
Ymke de JOng

Symeon Kourmoulakis

Doktorand

Department of Molecular Biosciences, The Wenner-Gren Institute
Symeon Kourmoulakis

Gintare Lasaviciute

Postdoc

Department of Molecular Biosciences, The Wenner-Gren Institute
Gintare Lasaviciute

Pilar López Hernández

PhD student

Department of Molecular Biosciences, The Wenner-Gren Institute

Qasi Khaleda Rahman

Forskare

Department of Molecular Biosciences, The Wenner-Gren Institute
QKR

Manuel Mata Forsberg

Researcher

Department of Molecular Biosciences, The Wenner-Gren Institute
Manuel Mata Forberg

Nogol Salehi

Student

Department of Molecular Biosciences, The Wenner-Gren Institute

Sevasti Telli

Student

Department of Molecular Biosciences, Wenner-Grens institute

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Publications

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