Research group Group Bengtsson
Obesity is a major inducer of type II diabetes and it is estimated by the World Health Organization that over 500 million people worldwide suffer from either of these disorders, with the incidence increasing dramatically over the last 10 years.
Group description
Group Bengtsson has been conducting innovative research into diabetes and obesity for over a decade, focusing on β-adrenergic receptors and their role in glucose uptake within skeletal muscle and brown fat. This receptor pathway, activated by the sympathetic nervous system, functions independently of insulin, and can potentially help manage blood glucose levels in type 2 diabetes.
Employing advanced techniques and both in vitro and in vivo methodologies, we are studying this pathway and its various components. Our research involves examining different agonists and their respective signaling profiles.
Our understanding of β-adrenergic receptors has broadened our research scope to include other organs such as the brain, liver, and pancreas. We are specifically investigating how small adrenergic ligands activate different intracellular pathways to promote beneficial physiological outcomes, like reducing lipid droplet sizes in the liver, with minimal side effects.
Another significant aspect of the group's research is our exploration into the potential of silica particles for improving metabolic health. These porous particles can capture metabolic enzymes, with the potential to slow down metabolism. This innovative approach has already demonstrated several benefits in humans, including the prevention of glucose spikes after meals, overall reduction in blood glucose levels, and facilitation of fat loss.
Throughout the years, we have developed and evaluated a variety of unique strategies to combat metabolic diseases. These strategies employ both silica-based methods and small molecules. The pivotal discoveries made in this process have inspired Tore Bengtsson to establish collaborations between international research organizations and commercial entities for the treatment of metabolic diseases.
Group members
Group managers
Tore Bengtsson
Professor
Members
Pia Andersson
Guest researcher
Jeanha Baek
Project leader
Federico Bocci
Student
Marcelo Freitas Montenegro
Researcher
Muhammad Hamza Bokhari
PhD student
Anna Ioannidou
Gästforskare
Anastasia Kalinovich
Guest researcher
Christine Kallenberg
Student
Vera Landin
Student
Aikaterini Motso
Doktorand
Diane Natacha Alleluia
Laboratorietekniker
Ghislaine Robert-Nicoud
Gästforskare
Anna Sandström
Laboratory technician
Tanishk Sharma
Praktikant
Klara Tistrand
Student
Zhengbing Zhuge
Forskningsassistent
