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Marcelo Freitas MontenegroResearcher

About me

Dr. Marcelo Montenegro is a pharmacologist who focuses on studying the cardiovascular system and finding better treatments for cardiovascular diseases. He has researched an alternative pathway for nitric oxide (NO) synthesis, known as Nitrate-Nitrite-Nitric oxide, and investigated how free radicals impact NO bioavailability in healthy and diseased conditions. Currently, he is researching the potential exploitation of alternative signaling pathways for adrenoreceptors to treat diabetes and hypertension at Stockholms Universitet. Dr. Montenegro has published over 50 scientific articles in internationally recognized journals, which you can find using the link below:

List of Publications

Publications

A selection from Stockholm University publication database

  • Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats

    2023. Laisla Zanetoni Martins (et al.). International Journal of Molecular Sciences 24 (16)

    Article

    Preeclampsia is a maternal hypertension disorder associated with vascular dysfunction and fetal and placental growth restrictions. Placental ischemia is suggested as the primary trigger of preeclampsia-associated impairments of both endothelium-derived nitric oxide (NO) and the vascular activity of extracellular matrix metalloproteinase-2 (MMP-2). Reduced uteroplacental perfusion pressure (RUPP) is a placental ischemia model of preeclampsia. Reduction of sodium nitrite to NO may occur during ischemic conditions. However, sodium nitrite effects in the RUPP model of preeclampsia have not yet been investigated. Pregnant rats were divided into four groups: normotensive pregnant rats (Norm-Preg), pregnant rats treated with sodium nitrite (Preg + Nitrite), preeclamptic rats (RUPP), and preeclamptic rats treated with sodium nitrite (RUPP + Nitrite). Maternal blood pressure and fetal and placental parameters were recorded. Vascular function, circulating NO metabolites, and the gelatinolytic activity of vascular MMP-2 were also examined. Sodium nitrite attenuates increased blood pressure, prevents fetal and placental weight loss, counteracts vascular hyper-reactivity, and partially restores NO metabolites and MMP-2 activity. In conclusion, sodium nitrite reduction to NO may occur during RUPP-induced placental ischemia, thereby attenuating increased blood pressure, fetal and placental growth restriction, and vascular hyper-reactivity associated with preeclampsia and possibly restoring NO and MMP-2 activity, which underlie the blood pressure-lowering effects.

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