Abstract

The era of personalized medicine promises bespoke therapeutic interventions, tailored to an individual’s genetic makeup. This lecture will delve into the use of mouse models, specifically focusing on the Collaborative Cross, to understand the genetic and environmental nuances of diverse diseases. The Collaborative Cross offers a powerful resource, encompassing a broad genetic diversity, making it an ideal tool for dissecting complex traits and genetic interactions, thereby paving the way for targeted therapies.

Transitioning from animal models, we will explore recent cutting-edge technological advancements, including Natera’s Renasight; how it harnesses the power of genetic testing and big data analytics. This analysis suite stands out as a beacon in kidney disease prediction, identifying individuals at risk of developing chronic kidney disease, facilitating early intervention, and personalized treatment strategies.

In combining insights from both mouse models and human-centric technologies, this lecture aims to paint a holistic picture of the current landscape and future potential of personalized medicine. It will highlight the confluence of basic research and technological innovation, driving the future of healthcare towards more precise and individualized solutions.