Human biological aging: quantifications, health predictions and interventions

Sara Hägg is an associate professor (docent) in molecular epidemiology at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. On Wednesday, April 6th, she visits the Department of Public Health Sciences, with a presentation titled "Human biological aging: quantifications, health predictions and interventions".

Time and place: Wednesday April 6th 2022, 13:30 -14:30 in Lecture room, level 2, house 4 at Campus Albano.
The seminar is also available via Zoom: https://stockholmuniversity.zoom.us/j/68236175540

More information about Sara Hägg

Sara Hägg, Karolinska Institutet

Abstract

Human aging is characterized by a gradual loss of function from cells to organs to whole body systems. Biological aging processes include mitochondrial dysfunction, epigenetic alterations, telomere shortening, metabolic dysregulation, cellular senescence, genomic instability, and stem cell exhaustion that all change during aging. Several of these processes are possible to measure in human cohorts of aging using different biomarker assessments such as DNA methylation data for epigenetic clock measurements and composite scores of blood, urine and clinical biomarkers. Different biological age quantifications are correlated with each other but may also capture different aspects of aging. Moreover, they are associated with health-related outcomes such as disease diagnoses and mortality. Studies are also emerging showing that life-style factors and different interventions may change the biological age level. However, conclusions on whether or not those changes are causally related to better health and increased survival is currently not known.

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