Deniz OzataDocent

Importantly, A-MYB–TCFL5 axis regulates ~100 specialized genes that produce pachytene PIWI-interacting RNAs (piRNAs) that guide PIWI proteins to cleave target transcripts.

We recently discovered that a novel testis-specific transcription factor TCFL5, expressed in pachytene stage of meiosis, collaborates with the transcription factor A-MYB via a set of interlocking positive feedback and coherent feedforward loops to regulate meiotic gene expression program.