Profiles

David Drew

David Drew

Professor in Biochemistry

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Works at Department of Biochemistry and Biophysics
Telephone 08-16 22 95
Email david.drew@dbb.su.se
Visiting address Svante Arrhenius väg 16
Room A553
Postal address Institutionen för biokemi och biofysik 106 91 Stockholm

Research

Structure and Mechanism of Solute Carrier (SLC) Transporters

SLC transporters are the targets for many therapeutics and they often play a major role in drug pharmacokinetics. Understanding the mechanisms by which SLC transporters shuttle and move ions, drugs, and natural compounds across membranes is of fundamental importance. Because of the technical difficulties in working with membrane proteins our mechanistic understanding is very limited. The goal of my research is to investigate the alternating access-mechanism of solute transporters for sugars and ions, which are critical to cell homeostasis and their dysfunction is associated with human diseases, such as cancer and diabetes. To achieve this we combine crystal and cryo EM structures with biochemical and biophysical techniques. These goals are facilitated by the development of novel methods to aid functional and structural investigation of SLC transporters.

Popular descriptions of our work on transporters 

https://www.youtube.com/watch?v=fwW86e3tFv4

https://www.su.se/forskning/profilområden/biologiska-membraner/forskning-som-lär-oss-mer-om-cellens-dörrar-1.347363

https://www.svd.se/genombrott-kan-leda-till-ny-malariamedicin

https://www.nature.com/articles/d41586-020-00148-8

 

Current group members

Magnus Claesson, Lab Manager

Dohwan Ahn, Postdoc

Roman Fudim, Postdoc

Ashutosh Gulati, Postdoc

Rei Matsuoka, Postdoc

Rachel North, Postdoc

Laura Orellana, Postdoc

Jan Skerle, Postdoc

Albert Suades, Postdoc

Hyunku Yeo, Postdoc

Yurie Chatzikyriakidou, PhD Student

Sukkyeong Jung, PhD Student

Surabhi Kokane, PhD Student

Sarah McComas, PhD Student

Pascal Meier, PhD Student

Iven Winkelmann, PhD Student

 

Selected Publications

Qureshi A, Suades A, Matsuoka R, Brock L, McComas S, Nji E, Orellana L, Claesson M, Delemotte L, Drew D

The molecular basis for sugar import in malaria parasites

Nature. 578, 321-325 (2020).

Nji E, Gulati A, Qureshi A. Coincon, M, Drew D

Structural basis for the delivery of activated sialic acid into Golgi lumen. 

Nature Structure & Molecular Biology 26, 415-423 (2019).

Nji E, Chatzikyriakidou Y, Landreh M, Drew D.

An engineered thermal shift screen reveals specific lipid preferences of eukaryotic and prokaryotic membrane proteins   

Nature Communications 9, 4253 (2018).

Gupta G, Donlan J.A, Hopper J, Uzdavinys P, Landreh M, Struwe W, Drew D, Stansfeld P, Robinson C.V.

The role of interfacial lipids in stabilising membrane protein oligomers. 

Nature 541, 421-423 (2017). 

Drew D, Boudker O.

Shared Molecular Mechanisms of Membrane Transporters. 

Annu. Reviews. in Biochem. 85(1) (2016). 

Coincon M, Uzdavinys P, Nji E, Dotson D.L, Winkelmann I, Abdul-Hussein S, Cameron A.D, Beckstein O, Drew D.

Crystal structures reveal the molecular basis of ion-translocation in sodium/proton antiporters. 

Nature Structure & Molecular Biology 23, 248-55 (2016).

Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien S, Qureshi A.A, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Unno H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D.

Structure and mechanism of the mammalian fructose transporter GLUT5. 

Nature526, 397-401 (2015).             

Lee C, Kang HJ, von Ballmoos C, Newstead S, Uzdavinys P, Dotson D, Iwata S, Beckstein O, Cameron A.D, Drew D

A two-domain elevator mechanism for sodium/proton antiport. 

Nature501, 573-7 (2013).

Hu NJ, Iwata S, Cameron A.D, Drew D

Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.

Nature 478, 408-11 (2011).

 

Funding Sources

European Research Council
Swedish Research Council
The Knut and Alice Wallenberg Foundation
The Wenner-Gren Foundation
Novo Nordisk Foundation
 

Files

  • CV (141 Kb)

Last updated: April 23, 2020

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