Research
Structure and Mechanism of Solute Carrier (SLC) Transporters
Secondary transporters are the targets for many therapeutics and they often play a major role in drug pharmacokinetics. Understanding the mechanisms by which secondary transporters shuttle and move ions, drugs, and natural compounds across membranes is of fundamental importance. Because of the technical difficulties in working with membrane proteins our structural understanding is very limited. The goal of my research is to investigate the alternating access-mechanism of solute transporters which are critical to cell homeostasis and their dysfunction is associated with human diseases, such as cancer and cardiovascular heart disease. To achieve this we combine crystal and cryo EM structures with biochemical and biophysical techniques. These goals are facilitated by the development of novel methods to aid functional and structural investigation of transporters.
Popular descriptions of our work on transporters
https://www.youtube.com/watch?v=fwW86e3tFv4
Latest news 2019
ERC Consolidator funding "EXCHANGE" to establish and dissect the dynamics and allosteric regulation of sodium/proton exchangers
https://www.dbb.su.se/about-us/news/david-drew-receives-erc-consolidator-grant-1.417884
Group members
Magnus Claesson, Lab Manager
Mathieu Coincon, Researcher
Dohwan Ahn, Postdoc
Roman Fudim, Postdoc
Ashutosh Gulati, Postdoc
Rei Matsuoka, Postdoc
Laura Orellana, Postdoc
Jan Skerle, Postdoc
Albert Suades, Postdoc
Hyunku Yeo, Postdoc
Yurie Chatzikyriakidou, PhD Student
Sarah McComas, PhD Student
Pascal Meier, PhD Student
Abdul Aziz Qureshi, PhD Student
Iven Winkelmann, PhD Student
Selected Publications
Nji E, Gulati A, Qureshi A. Coincon, M, Drew D.
Structural basis for the delivery of activated sialic acid into Golgi lumen.
Nat Struct Mol Biol. 26, 415-423 (2019).
Gupta G, Donlan J.A, Hopper J, Uzdavinys P, Landreh M, Struwe W, Drew D, Stansfeld P, Robinson C.V.
The role of interfacial lipids in stabilising membrane protein oligomers.
Nature 19, 421-423 (2017).
Drew D, Boudker O.
Shared Molecular Mechanisms of Membrane Transporters.
Annu. Reviews. in Biochem. 85(1) (2016).
Coincon M, Uzdavinys P, Nji E, Dotson D.L, Winkelmann I, Abdul-Hussein S, Cameron A.D, Beckstein O, Drew D.
Crystal structures reveal the molecular basis of ion-translocation in sodium/proton antiporters.
Nat Struct Mol Biol. 23, 248-55 (2016).
Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien S, Qureshi A.A, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Unno H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D.
Structure and mechanism of the mammalian fructose transporter GLUT5.
Nature, 526, 397-401 (2015).
Lee C, Kang HJ, von Ballmoos C, Newstead S, Uzdavinys P, Dotson D, Iwata S, Beckstein O, Cameron A.D, Drew D.
A two-domain elevator mechanism for sodium/proton antiport.
Nature, 501, 573-7 (2013).
Hu NJ, Iwata S, Cameron A.D, Drew D.
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.
Nature 478, 408-11 (2011).
Funding Sources
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